MALIGNANT MELANOMA

MALIGNANT MELANOMA - 3. MALIGNANT MELANOMA A tumour arising...

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Unformatted text preview: 3. MALIGNANT MELANOMA A tumour arising from melanocytes of the basal layer of the epidermis Less commonly uveal tract (eye) and meningeal membranes INCIDENCE Global incidence is rising relentlessly In NI, the incidence rate of melanoma is increasing faster than any other tumour 1996 181 new cases of malignant melanoma On average 28 deaths due to melanoma each year RISK FACTORS FOR MELANOMA Large numbers of benign naevi Freckles Clinically atypical naevi Severe sunburn Early years in a tropical climate Family history of MM PATIENT EDUCATION FAMILY HISTORY The majority of MMs occur in a sporadic pattern 2-10% of patients presenting with MM give a positive family history In part this may be due to the inheritance of specific MM susceptibility genes eg, CDKN2A on chromosome 9 Other reasons for familial clustering are atypical naevi and sun exposure NAEVI CONGENITAL NEVI occur in 1% of newborns. Tend to be large. Increased risk of MM ACQUIRED MELANOCYTIC NAEVI 30-50% of all MMs arise in pre-existing naevi. nos of naevi=risk MM ATYPICAL NAEVI / SYNDROME association between a familial occurrence of MM and an atypical naevus phenotype SUNSCREENS...
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This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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MALIGNANT MELANOMA - 3. MALIGNANT MELANOMA A tumour arising...

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