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MALIGNANT MELANOMA

MALIGNANT MELANOMA - 3 MALIGNANT MELANOMA • A tumour...

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Unformatted text preview: 3. MALIGNANT MELANOMA • A tumour arising from melanocytes of the basal layer of the epidermis • Less commonly – uveal tract (eye) and meningeal membranes INCIDENCE • Global incidence is rising relentlessly • In NI, the incidence rate of melanoma is increasing faster than any other tumour • 1996 – 181 new cases of malignant melanoma • On average 28 deaths due to melanoma each year RISK FACTORS FOR MELANOMA • Large numbers of benign naevi • Freckles • Clinically atypical naevi • Severe sunburn • Early years in a tropical climate • Family history of MM PATIENT EDUCATION FAMILY HISTORY • The majority of MMs occur in a sporadic pattern • 2-10% of patients presenting with MM give a positive family history • In part this may be due to the inheritance of specific MM susceptibility genes eg, CDKN2A on chromosome 9 • Other reasons for familial clustering are atypical naevi and sun exposure NAEVI • CONGENITAL NEVI – occur in 1% of newborns. Tend to be large. Increased risk of MM • ACQUIRED MELANOCYTIC NAEVI – 30-50% of all MMs arise in pre-existing naevi. ↑nos of naevi=↑risk MM • ATYPICAL NAEVI / SYNDROME –association between a familial occurrence of MM and an atypical naevus phenotype SUNSCREENS •...
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MALIGNANT MELANOMA - 3 MALIGNANT MELANOMA • A tumour...

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