Scleroderma - Scleroderma & Pregnancy Asim Iqbal Asim...

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Unformatted text preview: Scleroderma & Pregnancy Asim Iqbal Asim Iqbal Dept. Obstetrics & Gynecology Nishtar Hospital, Multan Pakistan [email protected] This Presentation is Dedicated to the Deceased Fetus of a Misfortunate Patient of Scleroderma. The Fetus Ended up in Intrauterine Death. Scleroderma Scleroderma Scleroderma: It is a term which includes a heterogenous group of limited and systemic conditions causing hardening of the skin. Systemic sclerosis: It is an extension of the disease process which implies involvement of both skin and other sites, particularly central internal organs. Scleroderma Types: ❇ Localized: The localized forms are Morphea and Linear, which affect only the skin (and sometimes the underlying tissues) but do not affect the internal organs ❇ Systemic: The systemic forms of Scleroderma cause fibrosis (scar tissue) to be formed in the skin and/or internal organs. The fibrosis eventually causes the involved skin or organs to harden Scleroderma New cases / million population /year Scleroderma Over all Male to female ratio 1:3 Reproductive age 1:8 Scleroderma Initiating factors are not known ❋ Numerous environmental agents (PVC) ❋ Drugs (Bleomycin, Pentezocine) ❋ Defective immunoregulation ❆ Autoantibodies ❆ Cellular autoimmunity ❆ Genetics, fetal cells , and viruses Scleroderma Uncontrolled and irreversible proliferation of normal connective tissue along with striking vascular changes • Collagen • Proteoglycans • Fibronectin • Laminin Scleroderma L y m p h o c t e s M n a r g The relationship between these inflammatory cells, their mediators ( ) and subsequent fibrosis may be critical in the initial stages of scleroderma Blood vessel Scleroderma Fibrous thickening affects skin, muscles, joints, tendons,...
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This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Scleroderma - Scleroderma & Pregnancy Asim Iqbal Asim...

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