Scleroderma - Scleroderma Pregnancy Asim Iqbal Dept...

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Scleroderma & Pregnancy Asim Iqbal Asim Iqbal Dept. Obstetrics & Gynecology Nishtar Hospital, Multan Pakistan [email protected]
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This Presentation is Dedicated to the Deceased Fetus of a Misfortunate Patient of Scleroderma. The Fetus Ended up in Intrauterine Death. Scleroderma
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Scleroderma Scleroderma: It is a term which includes a heterogenous group of limited and systemic conditions causing hardening of the skin.
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Systemic sclerosis: It is an extension of the disease process which implies involvement of both skin and other sites, particularly central internal organs. Scleroderma
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Types: Localized: The localized forms are Morphea and Linear, which affect only the skin (and sometimes the underlying tissues) but do not affect the internal organs Systemic: The systemic forms of Scleroderma cause fibrosis (scar tissue) to be formed in the skin and/or internal organs. The fibrosis eventually causes the involved skin or organs to harden Scleroderma
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New cases / million population /year Scleroderma
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Over all Male to female ratio 1:3 Reproductive age 1:8 Scleroderma
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Initiating factors are not known Numerous environmental agents (PVC) Drugs (Bleomycin, Pentezocine) Defective immunoregulation Autoantibodies Cellular autoimmunity Genetics, fetal cells , and viruses Scleroderma
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Uncontrolled and irreversible proliferation of normal connective tissue along with striking vascular changes Collagen Proteoglycans Fibronectin Laminin Scleroderma
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Lymphocytes Monocytes Macrophages The relationship between these inflammatory cells, their mediators ( ) and subsequent fibrosis may be critical in the initial stages of scleroderma Blood vessel Scleroderma
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Fibrous thickening affects skin, muscles, joints, tendons, nervous system and certain internal organs especially esophagus, intestinal tract, lungs and kidneys Scleroderma
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