Vesiculobullous diseases-1

Subepithelial blisters are common infiltration of

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Unformatted text preview: ra cellular odema. Subepithelial blisters are common Infiltration of inflammatory cells. ERYTEMA MULTIFORME ERYTEMA ERYTEMA MULTIFORME ERYTEMA MANAGEMENT No specific treatment required , if HSV inf.. No acycovir acycovir Systemic steroids may give relief to the Systemic fever. fever. In severe cases antibiotics are used to In prevent ant secondary infections. prevent Symptomatic –analgesics, antipyretics, Symptomatic antihistamines. EPIDERMOLYSIS BULLOSA BULLOSA EPIDERMOLYSIS BULLOSA EPIDERMOLYSIS Definition: A llarge group of clinically similar arge desquamating disease processes of the skin and mucosa that have in common the separation of the epithelium from the underlying connective tissue and the formation of large blisters that frequently result in extensive and often immobilizing scar formation. scar EPIDERMOLYSIS BULLOSA EPIDERMOLYSIS MAJOR CATEGORIES OF EPIDERMOLYSIS BULLOSA Type Genetic Pattern Separation Level Hereditary Hereditary Simplex Autosomal dominant Intraepithelial Junctional autosomal recessive lamina lucida Dystrophic autosomal dominant sublamina densa autosomal Acquired Acquired Acquisita None/autoimmune sublamina densa Defec. Structure Defec. linking proteins linking anchoring filaments type VII collagen type type VII collagen EPIDERMOLYSIS BULLOSA EPIDERMOLYSIS HEREDITARY TYPES: Congenital absence of components ACQUIRED TYPES: Autoantibodies (IgG; sometimes IgA) to Autoantibodies type VII collagen. type EPIDERMOLYSIS BULLOSA EPIDERMOLYSIS EPIDERMOLYSIS BULLOSA EPIDERMOLYSIS CLINICAL FEATURES 1.Epidermolysis Bullosa Simplex Mild form; autosomal dominant Sites of trauma/friction Involve hands, feet and neck; occ. knees Involve and elbows and Teeth not affected; intraoral blisters seen Appears during infancy EPIDERMOLYSIS BULLOSA EPIDERMOLYSIS EPIDERMOLYSIS BULLOSA EPIDERMOLYSIS 2. Junctional Epidermolysis Bullosa Severe form; autosomal recessive Haemorrhagic blisters; loss of nails, large Haemorrhagic blisters of face, trunk and extremities blisters Generalized scarring and atrophy Intraorally-haemorrhagic blisters of palate, Intraorally-haemorrhagic perioral and perinasal areas perioral Erupted teeth exhibit hypoplastic and severely Erupted pitted enamel prone to caries pitted EPIDERMOLYSIS BULLOSA EPIDERMOL...
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