Unformatted text preview: Vesiculobullous diseases
Dr.khurram zafar CLASSIFICATION OF VESICULOBULLOUS
A clear fluid lesion just below the
epithelium which ruptures to form an ulcer,
if this is smaller than 5mm then it is a
vesicle ,if larger than 5mm than it is a bulla CLASSIFICATION OF VESICULOBULLOUS
INTRA EPITHELIAL VESICLES: The lesion is formed
within the epithelium
Acantholytic vesicles : This is because of the break
down of specialized attachments called the
Nonacantholytic vesicles: It is usually in the viral
infections because of the death or the rupture of the
group of cells.
SUB EPITHELIAL VESICLES: Lesions formed between the
epithelium and the lamina propria eg:
Epidermolysis PEMPHIGUS VULGARIS
Common in Ashkenazi and Mediterranean jews .
Middle aged females.
Other variants are:
Pemphigus Foliaceus & Erthematosus
Paraneoplastic PEMPHIGUS VULGARIS
Painful ulcers or bulla are formed which are fluid
They can be formed any where in the oral cavity .
The bulla is rapidly ruptured leaving a collapsed roof
of grayish membrane with a red ulcerated base.The
ulcer may look like an apthous ulcer or may be large
Nikolsky sign is positive.
C/F PEMPHIGUS VULGARIS
Some time the ulcers are joined together to make a
confluence this condition is very painful.
It has a variable course might involve skin,
Protein/fluid,electrolyte and weight loss /secondary
Fatal if untreated.
Fatal PEMPHIGUS VULGARIS
PEMPHIGUS PEMPHIGUS VULGARIS
It is an autoimmune disease
There are circulating antibodies of type I...
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- Fall '11
- pemphigus vulgaris, Collagen, Pemphigus, epidermolysis bullosa, Chronic blistering cutaneous conditions