This preview shows page 1. Sign up to view the full content.
Unformatted text preview: ithelium
Alteration of rete pegs
Epithelium forms the roof of the blisters
Auto antibodies are formed against the
hemidesmosomes (BPAG-1,230kd;BPAG-2; 180kd.
in the later stages
Oral mucosa is the first site- lesions are rarely
Subepithelial bullae, ruptured in the later stages.
Bleeding in the bullae – bleeding blisters
Slow progress, skin involvement absent or rare
Involvement of eyes, nose larynx, pharynx and
Nikolsky sign is positive PEMPHGOID
occular involvement PEMPHGOID
Antibody antigen complex
Neutrophils & Eosinophils recruited
Release of proteases by the recruited cells
Sub epithelial blister formation PEMPHGOID
Ocular involvement –systemic steroids. ERYTEMA
MULTIFORME ERYTEMA MULTIFORME
Males adolosents , young adults are
affected ERYTEMA MULTIFORME
Unclear aetiology and pathogenesis
Infections like HSV can trigger this disease
Drugs like Sulphonamides ,barbiturates
Suggested cause is also given as to a type
III hypersensitivity reaction
III ERYTEMA MULTIFORME
Upper respiratory infection
Headache and malaise
Nausea and arthralgia
C/Fcont…d ERYTEMA MULTIFORME
Signs during the disease:
Red macules – 1cm or more in diameter with
Lips grossly swollen ,split crusted bleeding
Widespread fibrin covered erosions and
erythema in the mouth.
Conjunctivitis may be associated
Attacks recur at the intervals of several months
Usually self limiting. ERYTEMA MULTIFORME
ERYTEMA ERYTEMA MULTIFORME
Necrosis of the kertinocytes
Inter & int...
View Full Document
This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.
- Fall '11