Vitiligo Vulgaris

Vitiligo Vulgaris - Vitiligo Vulgaris By : Drew Compton...

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Unformatted text preview: Vitiligo Vulgaris By : Drew Compton Overview Vitiligo affects approximately 1% of the worldwide population. Depigmented patches on the hands, neck, genitalia, limbs, and face. Subtypes of Vitiligo Differ by anatomical location, and size of lesions Focal - a few isolated lesions Segmental unilateral distribution Acrofacial fingers and around mouth Universal almost total depigmentation Generalized most common, symmetrical distribution, form that will be discussed Psychological Aspects Can cause severe psychological and social damage Can result in discrimination especially in 3 rd world countries. Can be confused with Leprosy Cytology Normal skin is pigmented with melanin that is produced by melanocytes Detection by Masson Silver Stain Therefore white spots are due to melanocyte death Hypothesized Causes Neural Neuron terminates on melanocyte and causes neurotransmitter toxicity Autocytotoxic Defective enzyme in Hydrogen Peroxide breakdown. H 2 O 2 disrupts melanin production pathway Autoimmune Patients own immune system attacks and destroys the melanocytes Support for Autoimmune Theory...
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Vitiligo Vulgaris - Vitiligo Vulgaris By : Drew Compton...

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