Lymphomas - Lymphomas in the Mediastinum Mediastinal Large...

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Unformatted text preview: Lymphomas in the Mediastinum Mediastinal Large B Cell Lymphoma Mediastinal Large B Cell Lymphoma CD20 CD30 Immunhistochemische Differentialdiagnose Nodale Diffuse Large B Cell Lymphoma MLBCL CD20, CD79a +++ +++ IgM, Light chain ++ > ---- CD10 ++ > ---- ---- HLA-DR +++ Bcl-6 +++/- CD30, CD23 ----/+ ------------ +++ Möller, WHO 2004 Mediastinal Large B Cell Lymphoma Combined Hodgkin Lymphom & MLBCL CD30+CD15+CD20- CD30+CD15-CD20+ Hodgkin Lymphoma in a Mediastinal Lymph Node CD30 Hodgkin Lymphoma in the Thymus CD30 CK19 CK19 Pseudoepitheliomatous Hyperplasia & Thymic Cysts Search for Lymphoma, Thymoma, LCH, Metastasis, Germ Cell Neoplasia Immunhistochemische Differentialdiagnose Hodgkin Lymphoma (Classical Type; usually NS) MLBCL CD30 +++ +++ > ---- CD15 + > ---- ----- CD20 -/+ +++ CD79a ---- +++ PanLeu (CD45) ---- +++ Borderline Cases between HL and Mediastinal Large B Cell Lymphoma ? YES ! Distinct Gene Expression Profile of MLBCL (PMBL) Survival of MLBCL (PMBL) Patients Conclusions Distinct gene expression profile of PMBL (molecular diagnosis) PMBL patients are clinically distinct Close Relationship of PMBL to Hodgkin Lymphoma DD between MLBCL and ALCL CD3 CD30 ALK-1 Immunohistochemical Differential Diagnosis...
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This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Lymphomas - Lymphomas in the Mediastinum Mediastinal Large...

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