Tetanus - Tetanus Philip L. Pokorski, Ph.D. University of...

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Unformatted text preview: Tetanus Philip L. Pokorski, Ph.D. University of Michigan—Dearborn Department of Biology Tetanus Caused by Clostridium Tetani G ram positive Spore-forming Anaerobic rod Reservoir Spores of C. tetani are found in soils throughout the world Spores are very resistant to harsh conditions heat radiation chemicals drying Spores can survive for a long time in environment---100yrs possibly! Tetanus (cont’d) Entry of C. tetani into the body usually involves implantation of spores into a wound After gaining entry, C. tetani spores can persist in the body for months, waiting for the proper low oxygen growth conditions to develop Tetanus (cont’d) When the oxygen levels of the surrounding tissue is sufficiently low, the implanted C. tetani spore then germinates into a new, active vegetative cell that grows and multiplies and most importantly produces tetanus toxin Tetanus (cont’d) The virulence factor (toxin) responsible for the symptoms of tetanus is called tetanospasmin Tetanospasmin is an extremely...
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This note was uploaded on 01/02/2012 for the course STEP 1 taught by Professor Dr.aslam during the Fall '11 term at Montgomery College.

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Tetanus - Tetanus Philip L. Pokorski, Ph.D. University of...

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