BloodLecture

BloodLecture - Mannella et al. Theriot et al. Quantitative...

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Unformatted text preview: Mannella et al. Theriot et al. Quantitative Models of Biological Function APh/BE161: Physical Biology of the APh/BE161: Physical Biology of the Cell Cell Lecture 1: Anatomy of a Blood Test Lecture 1: Anatomy of a Blood Test-- Window on the Cell Theory Window on the Cell Theory The Beauty of the Beating Heart The Beauty of the Beating Heart Art is long, and Time is fleeting, And our hearts, though stout and brave, Still, like muffled drums, are beating Funeral marches to the grave. Henry Wadsworth Longfellow, ``A Psalm of Life Spin it down baby! Spin it down baby! After blood is extracted, anticoagulants such as heparin are added and then the suspension is spun in a centrifuge. The various interesting fractions are separated as a result of centrifugation and then they can be queried quantitatively resulting in the CBC. Figure from Junqueira and Carneiro, Basic Histology Results of a Complete Blood Count Results of a Complete Blood Count (CBC) Test (CBC) Test A Blood Smear A Blood Smear The light microscope is one of the greatest inventions in the history of science. Different cell types in the blood are revealed by different morphology. The invention of new ways of staining cells and their internal features has been another of the most important journeys in the history of science. (Golgi found ways to stain neurons, green fluorescent protein (GFP) is a great modern stain, etc. - really impressive.) Higher Resolution View of Higher Resolution View of Blood Cells Blood Cells Scanning Electron microscope used to view blood cells....
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BloodLecture - Mannella et al. Theriot et al. Quantitative...

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