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Unformatted text preview: BE/APh161: Physical Biology of the Cell Winter 2010 When: TTh, 8:30-10:25 AM. Because I will be on travel several times through- out the term, the hours are set so that we dont have to do makeup lectures. Who: You and me (Rob Phillips, x 3374, email@example.com , 159 Broad). The TAs for the course are Stephanie Johnson (x3333, Broad 132, firstname.lastname@example.org), Linda Song ( email@example.com) and Chao Liu (firstname.lastname@example.org). I am always happy to see you, but with cer- tainty, the best way to contact me is by email. After that, the best approach is to schedule a time to see me through my assistant, Katie Miller (x6337, email@example.com , 138 Broad). Where: 24 BBB What: See below! How: Lecture twice a week and weekly homework. No exams. Your grades will be based upon your homework grades. I will NOT accept ANY late homeworks (late means anytime after class starts the day the homework is due) unless you have a mindblowingly good excuse - this means a note from someone like a doctor or a Dean. (Please do not even ask me for an exten- sion - the answer is NO). As for collaboration, you may discuss the homework with others, but your explanations and derivations must be your own and your logic should be carefully explained and the significance of your results should also be explained. If you hand us a sloppy (either sloppy thinking or 1 writing) homework the grader will likely be unable to penetrate your logic and you will lose points. Reading: The course webpage will have a repository of required reading from the original literature. I am particularly persuaded that wide ranging reading will maximize the value of this course and will be providing a wide variety of opportunities for you to explore different topics. There are two main texts for the course: A Feeling for the Numbers in Biology by Ron Milo and Rob Phillips. This book is in the early stages of being written and is meant to complement the recently developed BioNumbers website (http://bionumbers.hms.harvard.edu/). Physical Biology of the Cell by Rob Phillips, Jane Kondev and Julie Theriot. There will be required readings from this text as well as many homeworks that come from the text itself. 1 Course Overview and Philosophy It is a wonderful time to be thinking about the workings of the living world. Historic advances in molecular biology, structural biology and the use of phys- ical techniques such as optical traps have provided an unprecedented window on the mechanics of the cell. The aim of this course is to study the cell and its components using whatever tools we need in order to make quantitative and predictive statements about cellular life. The main intellectual thread of the course will be the idea that the type of quantitative data which is becoming routine in biology calls for a corresponding quantitative modelling framework. The plan of the course is to elucidate general principles with exciting case studies. In 2009, having just completed my book Physicalexciting case studies....
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