GeneRegulationLecture2

GeneRegulationLecture2 - BE/APh161 Physical Biology of the...

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Unformatted text preview: BE/APh161 Physical Biology of the Cell Rob Phillips Applied Physics and Bioengineering California Institute of Technology Confronting theory and experiment: a simple case Vilar and Leibler (2003) Bintu et al. (2005) Oehler et al. (1994) Becker et al. (2005) fold change = (1+ R N e- b D e )- 1 Counting messenger RNAs in cells Golding et al. 05 Zenklusen et al. 08 Fixed cells Live cells Ido Golding Information Processing in Living Cells: Beyond First Approximations Caltech 11/2008 Department of Physics On the usefulness of models "It should be remembered that just as the Declaration of Independence promises the pursuit of happiness rather than happiness itself, so the iterative scientific model building process offers only the pursuit of the perfect model. For even when we feel we have carried the model building process to a conclusion, some new initiative may make further improvement possible. Fortunately to be useful a model does not have to be perfect. " George Box Rna distribution in yeast Zenklusen et al. 08 mRNA production in E.coli Golding et al. 05 mRNA production happens in bursts...
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GeneRegulationLecture2 - BE/APh161 Physical Biology of the...

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