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ML_biophys_motorlecture

ML_biophys_motorlecture - Motor proteins and...

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Motor proteins and mechano-chemistry Martin Lindén I. A mini-zoo of some motors, their biological functions, and some important experiments. II.Qualitative (toy) models, and ingredients in quantitative models. III.First passage time calculations (Bias: single motors and single molecule experiments)
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Part I: a small zoo of motor proteins.
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Motors in intracellular transport. The flagella rotary motor. Translocation through a pore, and the ratchet effect.
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Motors in intracellullar transport Lever arms ~8 nm ~36 nm + - microtubule Actin filament
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Motors in intracellullar transport Lever arms Driven by ATP Specific molecular track and direction Processive (in vitro) kinesin: ~100 steps/run myosin V: ~ 10 steps/run Works in small groups in vivo
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Watching single motors in vitro Nishiyama, Higuchi & Yanagida Nature Cell Biol 4:790 (2002)
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How does it walk? Actin filament Myosin V
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Hand over hand motion Flourophore attached to one of the heads of Myosin V: step size indicates hand-over-hand motion. Ahmet Yildiz, UC Berkeley “How Microtubular motors move” March 9, 4 PM, 106 Spalding
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E coli swimming is driven by a rotary motor Rotating filaments (flagella) form screw-like bundles
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