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Unformatted text preview: 1 Bi1: The Biology and Biophysics of Viruses Spring 2011 Problem Set 1: Cell Biology Due Tuesday, April 5 at 4:00 P.M. in the Bi 1 closet Name: ANSWER KEY _______________________________________________ Section # : ________________________________________________________ Mail Code : _______________________________________________________ TA Names : _______________________________________________________ Date and Time turned in : ___________________________________________ Number of pages including this one : __________________________________ AFTER YOU FINISH: How long did it take you to complete this problem set? __________________________ Go to the Bi1 moodle site at http://courses.caltech.edu/ and take the homework survey There are 2 questions. The number of parts to each question is listed at the beginning of each; be sure to answer all the parts! Grade: Problem 1 __________ Problem 2 __________ TOTAL: _________ HOMEWORK INSTRUCTIONS 1) Turn in your homework stapled to this cover page. 2) Use separate sheets of paper for your answers. 3) Write or type your answers neatly. 4) Put your name on each page of your answers. 5) Box your answers, please, so that the grader can find them. Points may be deducted if you dont follow these instructions! 2 Suggested reading: Ch 7, especially pg. 125, 136-141 in the textbook. Extra reading if you need more background to answer the questions: on the assignments page of the Bi1 website under Problem Set 1 ( http://www.its.caltech.edu/~bi1/assignments.html ). Proteins are used by living things as small as bacteria to things as large as giant sequoias. Essentially, proteins are molecular machines that work together to run the cell, allowing the organism to function. You can think of proteins as parts of a car engine each part looks different, and they all do separate jobs to make the engine run. Organelles are necessary to synthesize and modify proteins for function within the cell or for export. We will consider two organelles in this set: the endoplasmic reticulum (ER) and the Golgi apparatus. We will explore how a protein marked for modification is transported from the ER to the Golgi and how the protein moves through the Golgi. Problem 1. Endoplasmic Reticulum (30 points, 4 parts) Proteins that are translated on membrane-bound ribosomes enter the ER, where they either remain or are transported to the plasma membrane or membrane of another organelle. Proteins that are destined to be secreted or inserted into the plasma membrane have to traffic through the Golgi, where they will be modified, and then transported to their proper destination. You can think of the Golgi as a post office, where items in the form of proteins are packaged and shipped....
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