Lecture 2- Innate cells and complement

Lecture 2- Innate cells and complement - Kinetics of Innate...

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Kinetics of Innate and Adaptive Immune responses
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Bacterial Cell Structures
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Pattern Recognition Receptors (PRRs) bind molecules from microorganisms (not found in animals)
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Macrophages are the first cellular line of defense against infection Express pattern recognition receptors that sense molecules specific to pathogens Functions 1) Directly kill pathogens 2) Make cytokines and chemokines to recruit immune cells 3) Present antigens to adaptive immune cells
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Mechanisms of killing by phagocytes Acidification Reactive oxygen species Reactive nitrogen species Antimicrobial peptides (defensins) Enzymes (lysozyme)
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Recruitment of Innate Immune Cells to Infection Macrophages use pattern recognition receptors to sense molecules from infectious agents. Also directly kill pathogen. Soluble molecules (cytokines) are released that activate immune responses, and others (chemokines) create a gradient that attracts innate immune cells (neutrophils/NK cells) to the site of infection. Recruited cells leave bloodstream and enter tissue to combat infection. Amplify chemoattraction if infection is detected. Initiate adaptive immune responses (dentritic cells)
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Cytokines Cytokines are a family of small signaling molecules released by a variety cells of both the innate and adaptive immune response. Due to their central role in the immune system, they are critical for mediating a variety of inflammatory and anti-inflammatory processes, both local and at distant sites. . Involved in autocrine (acting on cell that makes the molecule),
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This note was uploaded on 01/03/2012 for the course BI 144 taught by Professor List during the Fall '10 term at Caltech.

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Lecture 2- Innate cells and complement - Kinetics of Innate...

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