Bi150 PS3_2011

Bi150 PS3_2011 - Bi150 Problem Set 3 Due: Tuesday, October...

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Bi150 Problem Set 3 Due: Tuesday, October 25 th , 2011, at 4:30 P.M. At the “Bi 150 Box” 3 rd floor of Kerckhoff in front of Room 326 (The building may be locked after 5 P.M.) INSTRUCTIONS Please: 1) Turn in your work with this cover page. 2) Use separate sheets of paper for the answer to each question, so that graders can work in parallel. 3) Write or type your answers neatly. 4) Put your name on each page of your answers . Name: ______________________________________________________ Section #: ___________________________________________________ Mail Code: ___________________________________________________ TA Name: ___________________________________________________ Date and Time turned in: _______________________________________ Number of pages including this one:_______________________________ There are 3 questions . Grade and Comments: 1__________________ 2__________________ 3__________________ Total: ______________
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Problem 1. Synaptic integration (1.5 points) A. (0.9 point) Inhibition Many inhibitory synapses in the CNS utilize GABA A and glycine receptors. Both GABA A and glycine receptor channels are permeable to Cl - ions. Calculate the Nernst potential for Cl - ions, E Cl , at 25 C. Consult the ionic concentrations on slide 5 of lecture 1. Resting membrane potentials of neurons are sometimes close to E Cl . When this is the case: a. How does the membrane voltage change if only GABA A receptors are activated? Consider a neuron receiving two excitatory inputs as shown below. The traces at the right show the membrane potential in the soma without inhibition. i) excitatory input 1 is stimulated alone ii) excitatory input 1 & 2 are stimulated b. For each trace, redraw the trace, then superimpose the trace if a GABAergic input is active at location A during the excitatory stimuli. c. For each trace, redraw the trace, then superimpose the trace if a GABAergic input is active at location B during the excitatory stimuli.
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This note was uploaded on 01/03/2012 for the course BI 150 taught by Professor Kennedy,m during the Fall '08 term at Caltech.

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Bi150 PS3_2011 - Bi150 Problem Set 3 Due: Tuesday, October...

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