Bi-150-molbiol

Bi-150-molbiol - 1 Bi 150 Lecture 0 An introduction to...

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Unformatted text preview: 1 Bi 150 Lecture 0 September 29, 2011 An introduction to molecular biology . . . but you will learn the cell biology in this course Lander et al 3 x 10 9 base pairs Humans have 22 pairs of chromosomes, plus the X and Y. Males are XY; females are XX. A. Each chromosome is “painted” with a unique combination of fluorescent dyes B. We have arranged the chromosomes to form pairs. © Garland; Little Alberts Fig 5-12 Little Alberts Fig 10-16 Genes can be localized crudely by hybridizing a fluorescent nucleotide probe to chromosomes 2 μ m 6 distinct genes are probed in this image Seuss 1959 5 Complete DNA sequence as scripture (surf NCBI) basic sequence RNA sequence protein sequence protein structure RNA splicing mutations that cause disease single-nucleotide polymorphisms (SNPs) orthologs in other species protein function proteins that bind to the sequence and regulate expression chromosomal location RNA abundance 6 22,000 genes x 400 codons/protein x 3 bases/codon = 26.4 million base pairs, or < 1% of the genome!...
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This note was uploaded on 01/03/2012 for the course BI 150 taught by Professor Kennedy,m during the Fall '08 term at Caltech.

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Bi-150-molbiol - 1 Bi 150 Lecture 0 An introduction to...

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