Lecture-01-2011-Bi-CNS150

Lecture-01-2011-Bi-C - H2O carbonyl K ion Bi/CNS 150 Lecture 1 Monday Revised The ionic basis of neuroscience Introduction to the course Please

Info iconThis preview shows pages 1–12. Sign up to view the full content.

View Full Document Right Arrow Icon
1 Bi/CNS 150 Lecture 1 Monday, September 26, 2011 Revised 9/26/2011 The ionic basis of neuroscience; Introduction to the course. Henry Lester H 2 O K + ion carbonyl Please note these revision dates
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
2 What is the most abundant molecule in an organism? Molecule Class Vote Comments
Background image of page 2
3 Who are the Bi/CNS 150 students? 5 graduate students Fields: 1 Bi 0 CNS 2 BSN 1 BMB 1 Ch Total undergraduate enrollment, 36 10 seniors, 17 juniors, 8 sophomores, 1 freshman Majors: 26 Biology, 4 CNS, 3 BE, 2 Ch, 1 ChE Preliminary numbers
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
4 Water is the most abundant molecule in an organism H 2 O MW = 18 Density ~ 1 kg/l Therefore the concentration of water in an aqueous solution is ~ (1000 g/liter )/(18 g/mol) = 55 mol/liter or 55 M. All other molecules in the body are at least 100 times less concentrated. Therefore we need to understand the properties of water.
Background image of page 4
5 Extracellular conc Intracellular (Cytosol) major monovalent Ions Na + 145 mM 15 mM K + 4 mM 150 mM Cl - 110 mM 10 mM divalent cations Ca 2+ 2 mM 10 -8 M Mg 2+ 2 mM 0.5 mM Other ions P i -2 2 mM 40 mM H + 10 -7 M 10 -7 M Protein 0.2 mM 4 mM Typical extracellular and cytosolic ion concentrations (mammalian cell)
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6 One clue to a cell’s ionic concentrations: Sea Water Sea Water Extracellular conc Intracellular (Cytosol) major monovalent Ions Na + 457 mM 145 mM 15 mM K + 9.7 mM 4 mM 150 mM Cl - 536 mM 110 mM 10 mM divalent cations Ca 2+ 10 mM 2 mM 10 -8 M Mg 2+ 56 mM 2 mM 0.5 mM Other ions P i -2 0.7 mM 2 mM 40 mM H + 10 -7 M 10 -7 M 10 -7 M Protein 0.2 mM 4 mM
Background image of page 6
7 Membranes provide a barrier to diffusion around cells, forming compartments Alberts 4 th 2-22 © Garland Alberts 4 th 11-1 © Garland Little Alberts 12-1 © Garland . . . But specialized proteins (channels and transporters) control the permeation of many molecules nicotine
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
8 External Monovalent cations: High Na + Low K + Na + Na + Na + Na + Na + Na + Na + Na + Internal: same as External Na + Na + Na + Na + Na + A Cell that Lacks Concentration Gradients K + K +
Background image of page 8
9 External Monovalent cations: High Na + Low K + Na + Na + Na + Na + Na + Na + Na + Na + K + Internal: Low Na + High K + K + K + K + K + Storing energy in a concentration gradient without osmotic stress: Simply reverse the ratio of Na + and K + K +
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
10 The “Na + pump” splits ATP to make a Na + and K + concentration gradient A transporter (or pump) protein moves a few ions for each conformational change 3 2 Alberts 4 th 11-8 © Garland
Background image of page 10
11 Na + Na + Na + Na + Na + Na + Na + Na + K + K + K + K + Converting a concentration gradient
Background image of page 11

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 12
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 01/03/2012 for the course BI 150 taught by Professor Kennedy,m during the Fall '08 term at Caltech.

Page1 / 32

Lecture-01-2011-Bi-C - H2O carbonyl K ion Bi/CNS 150 Lecture 1 Monday Revised The ionic basis of neuroscience Introduction to the course Please

This preview shows document pages 1 - 12. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online