Lecture-02-2011-Bi-CNS150

Lecture-02-2011-Bi-CNS150 - Bi CNS 150 Lecture 2 Wednesday...

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1 Bi / CNS 150 Lecture 2 Wednesday, September 28, 2011 Voltage-gated channels (no action potentials today) Henry Lester
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2 http://www.cns.caltech.edu/bi150/ The Bi / CNS 150 2009 Home Page Please note: Henry Lester’s office hours Read the book Mol Biol boot session Thursday evening, here.
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3 If you drop the course, or if you register late, please email Rell Parker (in addition to the Registrar’s cards). Also, if you want to change sections, please email Rell
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4 K + ions lose their waters of hydration and are co-ordinated by backbone carbonyl groups when they travel through a channel. H 2 O K + ion carbonyl From Lecture 1 Ion selectivity filter Gate
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5 [neurotransmitter] open closed chemical transmission at synapses: electric field open closed electrical transmission in axons: actually, E Major Roles for Ion Channels Future lectures:
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6 The electric field across a biological membrane, compared with other electric fields in the modern world 1. A “high-voltage” transmission line 1 megavolt = 10 6 V. The ceramic insulators have a length of ~ 1 m. The field is ~ 10 6 V/m . 2. A biological membrane The “resting potential” ~ the Nernst potential for K + , -60 mV. The membrane thickness is ~ 3 nm = 30 Å. The field is (6 x 10
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Lecture-02-2011-Bi-CNS150 - Bi CNS 150 Lecture 2 Wednesday...

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