Lecture-03-2011-Bi-CNS150

Lecture-03-2011-Bi-CNS150 - 1 Bi/CNS 150 Lecture 3 Friday...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: 1 Bi/CNS 150 Lecture 3 Friday, September 30, 2011 Action potentials Henry Lester Electrophysiology boot session, here Tues 7:30 PM Section assignments posted; if you’ve not requested a section, email Rell 2 Intracellular recording with sharp glass electrodes A cell is receiving stimuli from other cells, not from the experimenter (The spikes in these examples are about 100 mV in amplitude) Same data; choice of 3 formats. Media player required http://info.med.yale.edu/neuro http://info.med.yale.edu/neuro http://info.med.yale.edu/neurob V 3 Today’s reasoning employs electrical circuits http://theory.caltech.edu/people/politzer/calendar-c2010.pdf 4 open channel = conductor = 5 The miniature single-channel conductors add in parallel E Na (+60 mV) G Na = Σγ Na = G Na γ Na γ Na outside cytosol = inside mostly K + mostly Na + G K = Σγ K E K (- 60 mV) G K γ K γ K 6 C E G Na + ∆ V E G E G E G G G G K K Na Na Cl Cl K Na Cl = + + + + K + At DC, I C = C dV/dt = 0, so Cl- peak of action potential: Na + channels open too resting potential: K + channels open outside cytosol = inside The membrane potential at steady state (not at equilibrium) “after-hyperpolarization”: more K + channels open 7...
View Full Document

This note was uploaded on 01/03/2012 for the course BI 150 taught by Professor Kennedy,m during the Fall '08 term at Caltech.

Page1 / 18

Lecture-03-2011-Bi-CNS150 - 1 Bi/CNS 150 Lecture 3 Friday...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online