Lecture-29-2011-Bi-CNS150

Lecture-29-2011-Bi-CNS150 - David Helfgott plays...

Info icon This preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
1 David Helfgott plays Rachmaninov Piano Concerto #3 (Copenhagen Philharmonic, 1995) as in the movie “Shine” Born in Melbourne 1947 1962-1970 several schizophrenic episodes 1966-70 Royal College of Music 1970-1980 Hospitalized in Australia 1984- present concert pianist According to the biography by his wife, his present medication consists of: (1) chlorpromazine, a D2 receptor blocker for schizophrenia; See Figures 60-6, 60-7, 60-9 and (2) an anticholinergic for tardive dyskenesia.
Image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
2 Bi/CNS 150: wrapping up Friday, December 2 Final exam posted, covers entire course, emphasizes 2 nd half Friday, December 9 Final exam due, 4:30 PM
Image of page 2
3 Bi/CNS 150 Friday December 2, 2011 Schizophrenia, a cognitive disorder Kandel, Chapter 60 Lecture combines ideas of 4 academic research psychiatrists: Eric Kandel, Columbia (our text) Robert Freedman, Univ. Colo. David Lewis, Univ. Pittsburgh J. Michael McIntosh, Univ. of Utah As dramatized by 3 movies: Shine, A Beautiful Mind, One Flew Over the Cuckoo’s Nest
Image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
4 Schizophrenia. 1. Clinical description 2. Genetics 3. Pathophysiology: a century of failed ideas 4. Biomarkers and animal models 5. Heterozygote advantage: none known 6. Therapeutic approaches
Image of page 4
5 1. Clinical description The range of clinical features shows that schizophrenia affects multiple complex brain systems (Many simulated interviews appear on Youtube; HAL has a videotaped interview) Motor abnormalities: Posturing, impaired coordination, “catatonia” Negative symptoms: Decreased motivation, diminished emotional expression Cognitive deficits: Impairments in attention, executive function, some types of memory Positive symptoms: Delusions, hallucinations, thought disorder Prodromal signs: “he was weird, even as a child” social isolation & withdrawal, impairment in roles of normal function; odd behavior & ideas; blunted affect; poor personal hygiene
Image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
6 “He saw the world in a way no one could have imagined.”
Image of page 6
7 Concordance for Lifetime Risk of Schizophrenia 0% 10% 20% 30% 40% 50% general population 1st cousins uncles/aunts nephews/nieces grandchildren half siblings parents siblings children fraternal twins identical twins shared DNA 100% 50% (1st-degree relatives) 25% 12.5% Like Figure 60-3 48% 17% 1% (independent of culture) 2. Genetics (David Helfgott’s father; John Nash’s son)
Image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
8 Molecular Neuroscience Clinical Neuroscience Human Genome and Associated Data
Image of page 8
9 We describe a map of 1.42 million single nucleotide polymorphisms (SNPs) distributed throughout the human genome, providing an average density on available sequence of one SNP every 1.9 kilobases. This high-density SNP map provides a public resource for defining haplotype variation across the genome, and should help to identify biomedically important genes for diagnosis and therapy. International HapMap project 3.1 1.0 A haplotype is a common pattern of several nearby SNPs: 2 SNPs, but only 3 of 4 possible haplotypes exist 2009
Image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
10 20% 80% 60% 40% 20% 80% 30% 70% Locus A Chomosome 12 no linkage to schizophrenia Locus B Chomosome 8 may be near a gene that helps to cause schizophrenia sequence A1 sequence A2 sequence A1 sequence A2 Controls Schizophrenics sequence B1 sequence B2 sequence B1 sequence B2 Hunting for Genes with SNPs, image 1
Image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern