Lecture-29-2011-Bi-CNS150

Lecture-29-2011-Bi-CNS150 - 1 David Helfgott plays...

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Unformatted text preview: 1 David Helfgott plays Rachmaninov Piano Concerto #3 (Copenhagen Philharmonic, 1995) as in the movie Shine Born in Melbourne 1947 1962-1970 several schizophrenic episodes 1966-70 Royal College of Music 1970-1980 Hospitalized in Australia 1984- present concert pianist According to the biography by his wife, his present medication consists of: (1) chlorpromazine, a D2 receptor blocker for schizophrenia; See Figures 60-6, 60-7, 60-9 and (2) an anticholinergic for tardive dyskenesia. 2 Bi/CNS 150: wrapping up Friday, December 2 Final exam posted, covers entire course, emphasizes 2 nd half Friday, December 9 Final exam due, 4:30 PM 3 Bi/CNS 150 Friday December 2, 2011 Schizophrenia, a cognitive disorder Kandel, Chapter 60 Lecture combines ideas of 4 academic research psychiatrists: Eric Kandel, Columbia (our text) Robert Freedman, Univ. Colo. David Lewis, Univ. Pittsburgh J. Michael McIntosh, Univ. of Utah As dramatized by 3 movies: Shine, A Beautiful Mind, One Flew Over the Cuckoos Nest 4 Schizophrenia. 1. Clinical description 2. Genetics 3. Pathophysiology: a century of failed ideas 4. Biomarkers and animal models 5. Heterozygote advantage: none known 6. Therapeutic approaches 5 1. Clinical description The range of clinical features shows that schizophrenia affects multiple complex brain systems (Many simulated interviews appear on Youtube; HAL has a videotaped interview) Motor abnormalities: Posturing, impaired coordination, catatonia Negative symptoms: Decreased motivation, diminished emotional expression Cognitive deficits: Impairments in attention, executive function, some types of memory Positive symptoms: Delusions, hallucinations, thought disorder Prodromal signs: he was weird, even as a child social isolation & withdrawal, impairment in roles of normal function; odd behavior & ideas; blunted affect; poor personal hygiene 6 He saw the world in a way no one could have imagined. 7 Concordance for Lifetime Risk of Schizophrenia 0% 10% 20% 30% 40% 50% general population 1st cousins uncles/aunts nephews/nieces grandchildren half siblings parents siblings children fraternal twins identical twins shared DNA 100% 50% (1st-degree relatives) 25% 12.5% Like Figure 60-3 48% 17% 1% (independent of culture) 2. Genetics (David Helfgotts father; John Nashs son) 8 Molecular Neuroscience Clinical Neuroscience Human Genome and Associated Data 9 We describe a map of 1.42 million single nucleotide polymorphisms (SNPs) distributed throughout the human genome, providing an average density on available sequence of one SNP every 1.9 kilobases. This high-density SNP map provides a public resource for defining haplotype variation across the genome, and should help to identify biomedically important genes for diagnosis and therapy....
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This note was uploaded on 01/03/2012 for the course BI 150 taught by Professor Kennedy,m during the Fall '08 term at Caltech.

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Lecture-29-2011-Bi-CNS150 - 1 David Helfgott plays...

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