BMB170a_2011_Final

BMB170a_2011_Final - Final BMB 170 READ INSTRUCTIONS FIRST!...

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Final BMB 170 1 of 5 READ INSTRUCTIONS FIRST!!!!!!!!!!!!!!!!
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Final BMB 170 3 of 5 1. Proteins (25 points) a) Identify the kind of secondary structure, or lack thereof, you would predict based on the following three sequences. Which sequence would you expect to bind a metal? Why? i. TVSKITNDLNELADTI ii. ACYNCGQPGHPSRECPT iii. KLTVRLNISVE b) Indentify the following amino acids and label all of the dihedral angles ( Φ , Ψ & Χ s don’t worry about the direction convention) and the predicted secondary structure based on the given angles. i. Φ =-90 Ψ =90 ii. Φ =-90 Ψ =-30 iii. Label the N and C termini in this poly-alanine alpha-helix. c) Briefly describe the hydrophobic effect in terms of protein structure in water. Why do denaturants like urea or guanidinium chloride work? Consider free energy costs in your answers. d) Describe the steps of protein folding in vitro as one quickly lowers denaturant concentration. How is this different from folding in vivo ? What role do chaperones play? e) Describe a reason why a protein
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This note was uploaded on 01/03/2012 for the course BI 170a taught by Professor List during the Fall '09 term at Caltech.

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BMB170a_2011_Final - Final BMB 170 READ INSTRUCTIONS FIRST!...

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