{[ promptMessage ]}

Bookmark it

{[ promptMessage ]}

BMB170a_2011_LECTURE6

BMB170a_2011_LECTURE6 - 5)565/6789(<&$/3...

Info icon This preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
!""#$"%&$' )*+,' -./"*0$#' 1%#"$ 2#*&$/3 %''$04./$' 5)565/6789:;% <#*&$/3' 1$=&>#$ [email protected] -=& 9A
Image of page 1

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
B> !" $% C%&>#$ D&#>=& 5/*. EF;;;G :H99:FI: E9,JAG D$=5 D$=! )*K/L$K ,#*0 M/=N3$# O D=8$N0%3 D=/$3=$ EF;;PG A9;H9QPFI? 5%=&$#/%. 2*'&I&#%3'.%+*3%. &#%3'.*=%+*3 D$=5 '&%4/./R$' >3,*.K$K '&%&$ ,*# K$./S$#T &* 0$04#%3$ D$=! =%>'$' #$.$%'$
Image of page 2
D$=5 UTK#*28*4/= '>#,%=$ *3 '/K$ <#$'>0$K &* '$V>$'&$# ,*.K/3" /3&$#0$K/%&$' ,*# 0$04#%3$ K$./S$#T UTK#*28*4/= UTK#*28/./= B> !" $% C%&>#$ D&#>=& 5/*. EF;;;G :H99:FI: E9,JAG
Image of page 3

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
W#/""$# ,%=&*# 5%3 .%4H X$#4/&R !" $% C%&>#$ EF;;QG QA9HPY;I? E9ZF? O 9ZF4G W#/""$# ,%=&*# ,*>3K /3 %.. $>4%=&$#/% )$04$# *, % "#*>2 *, #/4*'*0$ %''*=/%&$K =8%2$#*3$' 5/3K' &* P;D '>4>3/& %& $J/& &>33$. U$.2' 3%'=$3& 2#*&$/3' ,*.K UTK#*28*4/= UTK#*28/./=
Image of page 4
W#/""$# ,%=&*# 0$=8%3/'0 W#/""$# ,%=&*# Z%/&' %& $J/& &>33$. 7%S/&T ,%=/./&%&$' ,*.K/3" M8$3 &8$ 3%'=$3& K*0%/3 /' 4/" $3*>"8 WX ,%..' *[ 5%3 .%4H X$#4/&R !" $% C%&>#$ EF;;QG QA9HPY;I?
Image of page 5

Info icon This preview has intentionally blurred sections. Sign up to view the full version.

View Full Document Right Arrow Icon
!0T.*/K K/'$%'$' Disease Aggregating protein or peptide Num res A Native structure of protein or peptide B Neurodegenerative diseases Alzheimer's disease c Amyloid ! peptide 40 or 42 f Nat Unf Spongiform encephalopathies c,e Prion protein or frags thereof 253 Nat Unf (res 1–120) and " -helical (res 121–230) Parkinson's disease c " -Synuclein 140 Nat Unf Dementia with Lewy bodies c " -Synuclein 140 Nat Unf Frontotemp dem. w/ Parkinsonism c Tau 352–441 f Nat Unf Amyotrophic lateral sclerosis c Superoxide dismutase 1 153 All- ! , Ig like Huntington's disease d Huntingtin with polyQ expansion 3144 g Largely Nat Unf Spinocerebellar ataxias d Ataxins with polyQ expansion 816 g,h All- ! , AXH domain (res 562–694); the rest are unk Spinocerebellar ataxia 17 d TATA box-bind prot w/ polyQ expansion 339 g " + ! , TBP like (res 159–339); unk (res 1–158) Spinal and bulbar muscular atrophy d Androgen receptor w/ polyQ expansion 919 g All- " , nucl receptor ligand-binding dom (res 669–919) Hered. Dentat.-pallidoluysian atr. d Atrophin-1 with polyQ expansion 1185 g unk Familial British dementia d ABri 23 Nat Unf Familial Danish dementia d ADan 23 Nat Unf Nonneuropathic systemic amyloidoses AL amyloidosis c Immunoglobulin light chains or frags 90 f All- ! , Ig like AA amyloidosis c frags of serum amyloid A protein 76–104 f All- " , unk fold Familial Mediterranean fever c frags of serum amyloid A protein 76–104 f All- " , unk fold Senile systemic amyloidosis c Wild-type transthyretin 127 All- ! , prealbumin like Familial amyloidotic polyneuropathy d Mutants of transthyretin 127 All- ! , prealbumin like Hemodialysis-related amyloidosis c ! 2-microglobulin 99 All- ! , Ig like ApoAI amyloidosis d N-term frags of apolipoprotein AI 80–93 f Nat Unf ApoAII amyloidosis d N-term frag of apolipoprotein AII 98 i unk ApoAIV amyloidosis c N-term frag of apolipoprotein AIV 70 unk Finnish hereditary amyloidosis d frags of gelsolin mutants 71 Nat Unf Lysozyme amyloidosis d Mutants of lysozyme 130 " + ! , lysozyme fold Fibrinogen amyloidosis d Variants of fibrinogen " -chain 27–81 f unk Icel. hered. cerebral amyloid angio. d Mutant of cystatin C 120 " + ! , cystatin like Nonneuropathic localized diseases Type II diabetes c Amylin, also (IAPP) 37
Image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern