BMB170a_2011_LECTURE14

BMB170a_2011_LECTURE14 - BMB 170a Lecture 14! Lipids and...

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BMB 170a Lecture 14 Lipids and Membranes, Nov 10, 2011 Lipids Bilayers Membrane proteins Membrane protein structure websites: – Stephen White lab at UC Irvine “Membrane Proteins of Known 3D Structure) http://blanco.biomol.uci.edu/Membrane_Proteins_xtal.html
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Electron tomographic reconstructions The Boulder Laboratory for 3D Electron Microscopy of Cells http://bio3d.colorado.edu Biomembranes - Yeast Cell
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C. jejuni PglB Knockout
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“Hydrophobic effect” and lipid bilayers “Ben Franklin Stilled the Waves” C. Tanford, Oxford (2004) Oil on water experiments - Benjamin Franklin 1774, Lord Rayleigh 1890, Agnes Pockels 1892, Irving Langmuir 1917 Cells – Have a barrier that contains cell contents Impermeable to large molecules and small polar molecules Permeable to Water Some molecules must be able to cross the membrane! – Contain two types of lipids (France early 1800s) Constant – phospholipids Variable – fats and oils (storage)
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“Hydrophobic effect” and lipid bilayers “Ben Franklin Stilled the Waves” C. Tanford, Oxford (2004) Charles Overton (1899) Cells completely permeable to many neutral molecules (cell type independent – anesthetics on tadpoles) Made the connection that increasing hydrophobicity decreased permeability Compared to oil permeability (membranes are similar to oils!) Gorter and Grendel (1924) Gorter was a famous pediatrician “We propose to demonstrate in this paper that the chromocytes of different animals are covered by a layer of lipoids just two molecules thick.” J Exp Med Measured red blood cell surface area by microscopy Isolated membranes and measured lipid surface area Argued that the membrane would be similar to fatty acid crystals (Bragg 1924)
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“Hydrophobic effect” and lipid bilayers “Ben Franklin Stilled the Waves” C. Tanford, Oxford (2004) Danielli and Davson (1935) Robertson (1959)
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BMB170a_2011_LECTURE14 - BMB 170a Lecture 14! Lipids and...

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