BMB170a_2011_PS4 - BMB 170a 2011 Problem Set 4: Lipids,...

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1 BMB 170a 2011 Problem Set 4: Lipids, Membranes, and Membrane Proteins 1. Lipid Molecules and Membrane Strucutres (25pts) a. Below is a representation of the shape of a lipid tail that might be attached to a head group represented as a green sphere. Propose a possible aggregate structure for each that it may self-assemble into. (4 pts) b. Describe the three pressure contributions that give rise to the lateral pressure profile of a lipid bilayer. Describe how they add up to give a net zero force. Draw a figure of a bilayer and label the location from where each pressure arises. (5 pts) c. Suppose you had a lipid bilayer composed of saturated sphingomyelin and the more unsaturated phosphatidylcholines mixed together, and then you added cholesterol to your membrane. What would happen? What drives your prediction energetically? (5 pts) d. What are the two main advantages of using triacylglycerols as stored fuels in an organism rather than polysaccharides like starch? (5 pts) e. Inside the head of sperm whales is a large organ known as the spermaceti organ, which contains as much as 3,600 kg of spermaceti oil. This oil is made up of triacylglycerols and waxes that are mainly unsaturated, making it a liquid at 37°C that begins to crystallize at about 31°C. These whales dive from 1,000 m to 3,000 m and can float at their chosen depth and wait for squid to swim but that they can eat. Why is their ability to float at any given depth unusual and what makes it possible? (6 pts) 2. Biological Membranes and Membrane Proteins
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BMB170a_2011_PS4 - BMB 170a 2011 Problem Set 4: Lipids,...

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