BMB170c_2011_04_07_LECTURE

BMB170c_2011_04_07_LECTURE - The behavior of a cell is...

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Unformatted text preview: The behavior of a cell is determined by its repertoire of proteins The behavior of a cell is determined by its repertoire of proteins Nerve cell Muscle cell A cell’s protein repertoire is determined by a balance between production of new proteins and elimination of existing ones New proteins made Old proteins degraded s 10’ 10’ Processes & Diseases Linked to Ubiquitin System cancers: sarcomas, leukemias: Mdm2 (ubi-ligase) renal carcinomas: VHL tumor suppressor (ubi-ligase) breast cancer: tumor suppressor BRCA1 (ubi-ligase) neurodegenerative diseases: Parkinson’s: UCH-L1 (de-ubi enzyme), Parkin (ubi-ligase) Angelmann’s syndrome: E6-AP (ubi-ligase) muscle atrophy: atrogin-1/MAFbx and MuRF1 (ubi-ligase) autoimmune disease: polyendocrinopathy, Aire (ubi-ligase) Cellular functions: cell cycle, localization, transcription, apoptosis, signaling, glucose sensing, circadiam rhythms The principal means of degrading proteins in cells is via the ubiquitin- proteasome system (UPS) The ubiquitin-proteasome system is vast. Of the ~22,000 genes encoded in each of your cells, about 1000 of them are involved in ubiquitin metabolism The Ubiquitin–Proteasome System altered function protein E2 E3 Ub Ub Ub Ub E1 E1 E2 E3 E2 protein...
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BMB170c_2011_04_07_LECTURE - The behavior of a cell is...

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