7 - 1 SYNTHESIS OF-ESTRONE In this course you will...

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1 SYNTHESIS OF (±)-ESTRONE In this course you will synthesize the human hormone estrone from readily available starting materials. Estrone is one of the general class of natural products of wide-ranging biological activity known as the steroids. Cholesterol represents another example and exhibits the typical A-B-C-D tetracyclic ring system which defines the steroid skeleton. CH 3 H H H HO CH 3 H H H O Estrone Cholesterol CH 3 HO H 3 C CH 3 H 3 C A D Estrone is one of the three primary human female sex hormones, collectively termed the estrogens, and is used therapeutically to rectify estrogen depletion as the result of, e.g., ovarian failure or menopause. 1 Estradiol and estriol comprise the remaining estrogens. The body of research directed toward the synthesis of steroids is immense, and has produced critical developments in chemistry, biology, and, ultimately, human medicine. 2 While estrone has been synthesized by many different routes, the present synthesis (Scheme 1) is probably the most practical, and has been conducted on an industrial scale.
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7 - 1 SYNTHESIS OF-ESTRONE In this course you will...

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