Chem 24 Lectures 1 and 2 Quantum and Molecular Orbitals

Chem 24 Lectures 1 and 2 Quantum and Molecular Orbitals -...

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1 Chem 24a Physical Chemistry for Biochemists Course Material Molecular Quantum Mechanics (follow on to last quarter) Spectroscopy fundamentals of the interaction of light with matter specific spectroscopies with a biochemical bent vibrational electronic NMR light scattering including circular dichroism light scattering including x-ray diffraction methods (week of Feb 15) Spectroscopy Methods that extend to single molecule – FRET, for example Instructor Jim Heath heath@caltech.edu 16A Noyes TAs Alex Sutherland (head TA) asutherl@caltech.edu Jessica Pfeilsticker pfeilst@caltech.edu
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2 Chem 24a Physical Chemistry for Biochemists Course Grading Homework 4 or 5 Sets 30% MidTerm (25%) and Final (30%) 1 Spectroscopy report/brief presentation (15%) Books for the course: required: Eisenberg and Crothers: Physical Chemistry with Applications to the Life Sciences: get for cheap as used on Amazon! great book, examples are a bit dated suggested: Engel Drobny Reid: Physical Chemistry for the Life Sciences (more modern and slick, but not nearly as good) Lecture notes will be made available within a day or two of the actual class (probably not before) Literature relevant to the course will be indicated as we go forward
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3 Report topic can be taken from the following subject areas, but the application should be biochemistry or biology focused. If you want to do a report on a topic not listed here, then just ask Prof Heath or one of the two TAs about it. light scattering x-ray diffraction NMR spectroscopy vibrational (infrared or Raman) spectroscopy circular dichroism dielectric spectroscopy electronic spectroscopy – fluorescence or absorbance (i.e. green fluorescent protein) Fluorescence Resonant Energy Transfer (FRET) Single Molecule Spectroscopies (could be fluorescence, FRET, Raman, etc.) Electron Spin Resonance etc. Pick one or two papers from the scientific literature (primary paper must not be a review paper) in which your spectroscopy technique is a key component of the research findings Pick your papers by Jan 20 – give the citation to Alex Sutherland (TA) Turn in report and ppt presentation by Feb 3 We will start presentations on Feb 8
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4 Assignment: Each student in this class will give one report to the class on a topic related to biomolecular spectroscopy. This assignment is worth 15% of your grade. It will involve a BRIEF oral presentation, and a 2-3 page written summary. The oral report guidelines (please follow): 4 powerpoint Slides Slide #1: Background of technique – equipment needed, what type of information can be extracted; how long has it been around. Slide #2: Your literature example of the technique – how was it applied? What was the biological system to which it was applied Slide #3: Calculations relevant understanding the data – all spectroscopy methods rely upon some physical model to explain the interaction of light with the experiment. That physical model can typically be expressed in mathematical terms.
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Chem 24 Lectures 1 and 2 Quantum and Molecular Orbitals -...

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