4 - ANNOUNCEMENTS LECTURE 4 1 RE QUIZ 1 PROF WILL CUT THIS...

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LECTURE 4 1. RE QUIZ 1: PROF WILL CUT THIS FRIDAY'S LECTURE ABOUT 5 MIN SHORT, AND TELL YOU WHAT WILL BE ON THE WED 9/7 QUIZ. ANNOUNCEMENTS: 2. OFFICE HRS 2 - 4 PM ON MONDAYS WILL BE IN 402 BIOTECH (NOT 202) ALL SEMESTER 3. ANY INTERESTED TRANSFER STUDENTS (OTHERS WELCOME TOO!): “HOW TO SUCCEED AT THIS PLACE", 2:55 - 4:10PM, FRIDAY 9/2 IN COMSTOCK B108. WEDNESDAY’S LECTURE: IONIZABLE GROUPS THE HYDROPHOBIC EFFECT TODAY: 1. WHAT CAN WE SAY ABOUT PROTEINS WITHOUT KNOWING THE 3D STRUCTURE? PEPTIDES PROTEIN STRUCTURE: WHAT IS 3D STRUCTURE?! 2. FINDING THE 3D STRUCTURE INTRO TO MYOGLOBIN ISOZYMES; GUESS PROTEIN FUNCTION; SPECIAL AA SEQUENCES; COMPUTE? X 5. CHECK OUT BLOCK & BRIDLE, TODAY AT 5:30PM IN 146 MORRISON 4. PyMOL REVIEWS: SUNDAY IN CARPENTER HALL COMPUTER LAB RED ROOM; TUESDAY IN 251 MALOTT: GETTING INTO MALOTT AFTER 4:30PM 7. NO NEED TO E-MAIL PROF RE EXAM CONFLICTS 6. LOOK INTO THE FOOD SCIENCE CLUB, TODAY AT 5:00PM IN 404 PLANT SCIENCE BLDG.
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MYOGLOBIN BEHAVIOR PROPERTIES: SHOW O BINDING TWO WAYS: 2 153 AA, MW 17,000 IN MUSCLE CELLS; STORES O 2 [O 2 ] IN WATER ~ 0.3mM [MbO 2 ] IN CELLS ~ 100mM 1 AS AN EQUATION: Mb + O 2 MbO 2 DEOXY FORM OXY FORM 2 AS A GRAPH 1.0 0.5 - - UNITS OF PRESSURE: 1 TORR = 1mmHg = 0.133 kPa TEXT USES kPa = kilo Pascal Hb Mb Mb RED BLOOD CELL
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HOW DOES O 2 BIND TO Mb? JARGON : NON-AA STRUCTURE COVALENTLY BOUND IN PROTEIN PROSTHETIC GROUP HOLOPROTEIN ENTIRE PROTEIN PLUS PROSTHETIC GROUP APOPROTEIN PROTEIN WITHOUT ITS PROSTHETIC GROUP e.g. "APOMYOGLOBIN" Fe 2+ IS USUALLY 6-COORDINATED 4 POSITIONS OCCUPIED BY HEME N 6 THEN: WHY NOT HAVE ONLY HEME FOR BINDING O 2 ?! HEME Fe-PROTOPORPHYRIN IX 1 2 3 4 6TH COORDINATION POSITION NOT OCCUPIED BY HEME OR BY Mb ATOMS: THIS IS WHERE O 2 BINDS 5TH POSITION IS N FROM HIS OF Mb 5
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BY ITSELF, IN WATER WITHOUT PROTEIN, HEME DOES NOT BIND O 2 !
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4 - ANNOUNCEMENTS LECTURE 4 1 RE QUIZ 1 PROF WILL CUT THIS...

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