9 - LECTURE 9 3 MEET WITH INTERESTED STUDENTS FRIDAY 9/16...

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Unformatted text preview: LECTURE 9 3. MEET WITH INTERESTED STUDENTS, FRIDAY 9/16, 2:55 - 4 PM, COMSTOCK B108: NEW UNDERGRAD RESEARCHERS-- WHAT IS EXPECTED OF YOU?! MONDAY’S LECTURE: ANNOUNCEMENTS: MANY PROTEINS HAVE MORE THAN ONE, SOMETIMES MANY, FOLDS IN ONE CHAIN ASSOCIATION OF MORE THAN ONE POLYPEPTIDE CHAIN = QUATERNARY STRUCTURE, IV CAN BE STABLE IV , e.g. HEMOGLOBIN CAN BE A TRANSIENT IV COMPLEX, e.g. INSULIN SIGNALING COMPLEX TODAY: PROTEIN IS STABLE, BUT NOT VERY! AND HOW DOES IT FOLD UP?!?! THERMODYNAMIC VIEW OF PROTEIN FOLDING: NATIVE STRUCTURE HAS LOWEST G o 2. TODAY: CORNELL HEALTH INTERNATIONAL GEN. BODY MEETING, 4:30PM 1. RE-GRADED QUIZZES--HOW TO GET THEM BACK? CHECK GREEN FOLDER ON FRONT DESK. BUT AFTER ~ ONE WEEK, THESE ALSO GO TO THE BIO CENTER RESERVE DESK. HOW TO DESCRIBE PROTEIN STABILITY WITH A GRAPH? SIMPLE EXAMPLE: POLY(GLU); SIDECHAIN CAN BE CH 2-CH 2-COOH OR CH 2-CH 2-COO- NOTE: STRUCTURAL COORDINATES SCALE IS ARBITRARY ! HERE WE LET “x” REPRESENT α-HELIX ON STRUCT. COORD AXIS MEANING OF STRUCTURAL COORDINATES AXIS: POSITIONS CLOSE ON AXIS ARE CLOSE IN STRUCTURE ; POSITIONS FAR APART ARE VERY DIFFERENT IN STRUCTURE. o G pH 3 STRUCTURAL COORDINATES x G o pH 7 STRUCTURAL COORDINATES x LOWER, OR MORE NEGATIVE, ON G o AXIS MEANS MORE STABLE WHY PLOT G o RATHER THAN G?!...
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell.

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9 - LECTURE 9 3 MEET WITH INTERESTED STUDENTS FRIDAY 9/16...

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