10 - ANNOUNCEMENTS 1. QUIZ LECTURE 10 2A 22.7 sd 5.4 2B...

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LECTURE 10 ANNOUNCEMENTS 1. QUIZ 2A 22.7 sd 5.4 2B 24.2 sd 5.0 2C 23.7 sd 4.8 2. NO LETTER GRADES AT THIS TIME. A VERY ROUGH IDEA OF WHERE YOU STAND: DIVIDE RAW SCORE BY MEAN NORMALIZED SCORE ("NS"); MID-RANGE FOR GRADE OF A, NS = 1.2; MID-RANGE FOR B+, NS = 1.0; MID-RANGE FOR GRADE OF C, NS = 0.8. THIS IS A ROUGH GUIDE . 3. THREE WEDNESDAYS WHEN THERE WILL NOT BE A QUIZ: 10/12 (DAY OF RETURN FROM FALL BREAK) 10/19 (DAY BEFORE THE MIDTERM EXAM) 11/23 (DAY WHEN THANKSGIVING RECESS BEGINS) 5. MEET TODAY WITH ANY INTERESTED STUDENTS TO DISCUSS "WHAT IS EXPECTED OF AN UNDERGRADUATE RESEARCHER?!", 2:55 - 4 PM IN B108 COMSTOCK. WEDNESDAY'S LECTURE: THERMODYNAMIC TREATMENT OF PROTEIN FOLDING PROTEINS CAN RENATURE ALL INFO FOR FOLD STRUCTURE IS IN AA SEQUENCE TODAY: WHY DO SOME PROTEINS NEED HELP TO FOLD? MOTION INSIDE PROTEINS! "PATHWAY" OF PROTEIN FOLDING? BUT THAT PROTEINS FOLD FAST, IN SECONDS-TO-MINUTES, IS NOT UNDERSTOOD 4. INTERESTED IN TELLURIDE HOUSE?
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BUT THIS REFOLDING TOOK 10 HR, vs 2 MIN IN A CELL REAL WORLD: REFOLDING NOT SO SIMPLE? 8M UREA + HO-CH CH SH 2 2 8M UREA + HO-CH 2 CH 2 SH UNFOLDED, INACTIVE UNFOLDED, INACTIVE DIALYZE, AIR OXIDIZE + S S S S S S S S S S S S S S S S S S S S S S S S S S S S DIALYZE, AIR OXIDIZE S S S S S S S S S S S S ACTIVE RIBONUCLEASE! STRUCTURE? NOT MUCH FOLDING! INSULIN RIBONUCLEASE 33 AA S S S S S S S S S S S S + 23 AA HAS 2 CHAINS REDUCES (DESTROYS) DISULFIDE BONDS SOME PROTEINS ARE 107 AA PRE PRO INSULIN 51 AA INSULIN 84 AA PRO INSULIN CANNOT FOLD WELL. SOME INFO FROM AA SEQ. HAS BEEN LOST! WHY NOT REFOLD?! RIBONUCLEASE, SHOWING THE 4 DISULFIDE BONDS IN SPHERES
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REAL WORLD: 2 ENZYMES SPEED UP FOLDING DISULFIDE ISOMERASE PROLYL ISOMERASE G o SPEEDS UP PEPTIDE cis - trans INTERCHANGE.
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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10 - ANNOUNCEMENTS 1. QUIZ LECTURE 10 2A 22.7 sd 5.4 2B...

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