11 - LECTURE 11 ANNOUNCEMENTS • READING& PROBLEMS AS...

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Unformatted text preview: LECTURE 11 ANNOUNCEMENTS : • READING & PROBLEMS AS IN LG FOR THIS WEEK; PyMOL #4, HEMOGLOBIN • ALL INFO ABOUT PROTEIN FOLDING IS IN THE AA SEQUENCE. BUT CORRECT DISULFIDES, AND CORRECT cis vs trans NEXT TO PROLINE ARE SLOW WITHOUT ENZYMES. • PROTEINS CAN FOLD IN A SHORT TIME, TYPICALLY SEC - MIN: NOT UNDERSTOOD! TODAY: • DETAILS OF FOLDING PROCESS? SEC STRUCTURE FORMS FIRST, OR "HYDROPHOBIC COLLAPSE" FIRST? THE "MOLTEN GLOBULE" STATE FORMS BEFORE NATIVE FOLD FRIDAY'S LECTURE: ** SOME DISEASES ARE CAUSED BY PROTEIN MISFOLDING: "AMYLOID DEPOSITS" AR AGGREGATES OF MISFOLDED PROTEIN. HUNTINGTON'S DISEASE, ALZEIMER'S, THE PRION DISEASES: PROTEINS ALL β PROTEIN FUNCTION CONNECTED TO PROTEIN STRUCTURE: START OF THE HEMOGLOBIN STORY • QUIZZES THAT HAVE BEEN REGRADED AND RECORDED ARE IN THE GREEN FOLDER; EACH FRIDAY, THESE WILL BE BROUGHT OVER TO THE BIOLOGY CENTER • MOVEMENTS WITHIN ALL PROTEINS; EXAMPLES OF HIV PROTEASE, HIV CAPSID, HEXOKINASE, AND Mb • MISFOLDING; ROLES OF MOLECULAR CHAPERONES TRANSPORT PROTEINS: THE O 2 CARRIERS • ROLE OF HEME • Mb SHAPED TO FIT HEME, HOLD IN CREVICE O 2 PRESSURE, mm Hg 25 50 75 100 θ = FRACTION OF HEMES SATURATED WITH O 2 1.0 0.5 Hb Mb IN O 2-STARVED TISSUE WANT IT SATURATED WITH O WANT IT SATURATED WITH O 2 IN LUNGS, BUT GIVING UP O IN LUNGS, BUT GIVING UP O 2 IN TISSUE IN TISSUE NOTICE THE SHAPE OF THIS CURVE: "SIGMOID" WHAT WOULD BE THE IDEAL PROPERTIES OF A MOLECULE DESIGNED TO PICK UP O 2 IN LUNGS, DELIVER O 2 TO THE TISSUE?...
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell.

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11 - LECTURE 11 ANNOUNCEMENTS • READING& PROBLEMS AS...

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