12 - ECTURE Saturday Sept.L24, 2011129 PM - 1 AM...

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LECTURE 12 ANNOUNCEMENTS 1. YOUR NEXT PyMOL EXERCISE: #4 HEMOGLOBIN. PRINT OUT THE INSTRUCTIONS. MONDAY’S LECTURE: COMPARISON OF STRUCTURE OF Mb WITH Hb α AND β CHAINS INTRODUCTION TO THE SIGMOID CURVE AND ION PAIRS IN DEOXY Hb TODAY: DETAILS REALLY DO MATTER! HEMOGLOBIN ACTION EXPLAINED BY ION PAIRS. COMPLETELY. ALMOST COMPLETELY. 2. PROF. FEIGENSON WILL MEET WITH ANY 3310 STUDENTS, THIS FRIDAY, 9/23 FROM 2:55 - 4PM IN COMSTOCK B108: “APPLYING TO GRADUATE SCHOOL-- WHAT ARE THEY LOOKING FOR?" 3. WANT TO GET EDUCATED ABOUT ISSUES IN AFRICA-- AND HAVE FUN? SATURDAY 9/24 FROM 9PM - 1AM IN BARTON HALL 4. WE JUST LEARNED THAT CIT CHANGED THE MAILBOX SYSTEM AFTER THE SEMESTER STARTED, CAUSING ALL VOH MESSAGES TO BE LOST. SORRY! THE VOH IS NOW FIXED. Saturday Sept. 24, 2011 9 PM - 1 AM
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WHY WOULD O 2 BINDING DISRUPT DISTANT ION PAIRS ?! i.e. HOW IS HEME CONNECTED TO SUBUNIT CONTACTS OF IV? EXPLANATION PROPOSED BY MAX PERUTZ, NOBEL PRIZE- WINNER WHO GREATLY INFLUENCED UNDERSTANDING OF Hb: PROXIMAL HIS IS BOUND TO Fe 2+ , MOVES WHEN O 2 BINDS, DRAGGING HELIX F, BREAKING SUBUNIT ION PAIRS
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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12 - ECTURE Saturday Sept.L24, 2011129 PM - 1 AM...

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