13 - ANNOUNCEMENTS: QUIZ 3: A 25.4 sd 3.7 LECTURE 13 B 25.7...

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LECTURE 13 WEDNESDAY’S LECTURE: ANNOUNCEMENTS: QUIZ 3: A 25.4 sd 3.7 B 25.7 sd 3.3 C 25.1 sd 3.8 PROF. FEIGENSON WILL MEET WITH ANY 3310 STUDENTS, TODAY, 9/23 FROM 2:55 - 4PM IN COMSTOCK B108: “APPLYING TO GRADUATE SCHOOL-- WHAT ARE THEY LOOKING FOR?" TODAY: ENZYMES! AN INTRO BOTH THE BOHR EFFECT AND HOW FETAL Hb GETS O 2 FROM THE MOTHER ARE EXPLAINED BY ION PAIRS AND THE T R TRANSITION INTRO TO KINETICS 2-STATE MODEL VS SEQUENTIAL MODEL FOR Hb BINDING O 2 THE T R TRANSITION IN Hb EVOLVED (AFTER Mb EXISTED) TO CREATE A CONTROLLED OXYGEN TRANSPORT MOLECULE NOTE: FOR Mb THERE CANNOT BE ANY COOPERATIVITY! LOOKING FOR AN ACTIVITY INVOLVING HEALTH OR HEALTH POLICY? LIKE TO WRITE? TUESDAY 9/27 AT 5:30PM, ROOM TBA
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ENZYMES! SUBSTRATE: ALIPHATIC, AROMATIC-OH C-OH IS e - DONOR REDOX RXN IS CATALYZED NAD + or NADP + IS e - ACCEPTOR 7. Membrane transporters + + 3.6.3 MEMBRANE TRANSPORTERS Na + K + ATPase 3.6 HYDROLYZE ACID ANHYDRIDES 3.6.4 HYDROLYZE ATP 3.6.5 HYDROLYZE GTP ON THIS PAGE: OFFICIAL 6 CATEGORIES FROM ENZYME COMMISSION, EC 2.7 TRANSFER PO4 2.7.1 ACCEPTOR -OH 2.7.1.2 SUBSTRATE GLUCOSE *7*. Transporters Na + K + ATPase REMOVE OR ADD A GROUP INTRAMOLECULAR REARRANGEMENT JOIN TWO MOLECULES
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THE EC NOMENCLATURE IS SYSTEMATIC. REAL BIOCHEMISTS ARE JARGON-HAPPY: EC 3.6.4.10 IS ALWAYS CALLED “hsp 70” EC 2.7.7.7 IS DNA POLYMERASE I, CALLED “POL I” VERY CONCISE ADDITIONAL INFO AT WIKI "EC NUMBER" OR GOOGLE “ENZYME COMMISSION” FOR MORE INFO WHAT ENZYME PROPERTIES DO WE WANT TO UNDERSTAND? 1. SPECIFICITY 2. CATALYSIS 3. CONTROL
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ABSOLUTE SPECIFICITY THE RANGE OF ENZYME SPECIFICITY e.g. NH 2 -C-NH 2 + 2H 2 O + H + 2NH 4 + + HCO 3 - O = UREASE ABSOLUTE FUNCTIONAL GROUP SPECIFICITY ALCOHOL DEHYDROGENASE O e.g. CH 3 -CH 2 -OH + NAD + CH 3 -CH + NADH + H + -CH 2 -OH + NAD + -CH + NADH
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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13 - ANNOUNCEMENTS: QUIZ 3: A 25.4 sd 3.7 LECTURE 13 B 25.7...

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