14 - LECTURE 14 ANNOUNCEMENTS: READING & PROBLEMS...

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LECTURE 14 FRIDAY’S LECTURE: GIVEN THAT ALL CHEMICAL REACTIONS IN LIFE ARE CATALYZED REACTIONS. NO EXCEPTIONS. HOW DO THESE CATALYSTS WORK? ENZYME COMMISSION NOMENCLATURE ENZYME SPECIFICITY ANNOUNCEMENTS: TODAY: PyMOL: ASSIGNMENT #5, THE PROTEIN DATA BANK INTRO TO RXN RATES GIBBS FUNCTION TRANSITION STATE WHY RXNS TAKE TIME TO OCCUR?! HOW CATALYSTS WORK HOW TO STUDY ENZYMES AS CATALYSTS AN INTERESTING SPEAKER THIS TUESDAY 9/27 AT 4:30PM IN HOLLIS E. CORNELL AUD.
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CATALYSTS LOWER TRANSITION STATE FREE ENERGY. THERE ARE ONLY TWO WAYS TO DO THIS: 1. DIRECTLY BIND THE TS 2. CHANGE THE RXN PATHWAY: 1 BINDING THE TS SIMPLE EXAMPLE FROM ORGANIC CHEM. ETHYLENE HYDROGEN ETHANE SIMPLE CASE OF “DIRECTLY BINDING THE TS”: REACTANTS HELD AT ~ SAME HEIGHT ABOVE Ni CRYSTAL SURFACE BY WEAK BONDING THE PARTICULAR ORIENTATION NECESSARY FOR RXN IS NOW MORE LIKELY! (ENTROPY OF TS REDUCED LESS UNLIKELY) UNCATALYZED TS CATALYZED TS , WITH REACTANTS AT SAME LEVEL ABOVE Ni SURFACE ENZYMES ALSO HOLD THEIR SUBSTRATES IN PRECISE ORIENTATION FOR RXN-- BUT THEY DO THIS IN 3 DIMENSIONS AND STABILIZE IT; NEW TS HAVING LOWER G o QuickTimeª and a decompressor are needed to see this picture. QuickTimeª and a decompressor are needed to see this picture. ENZYMES ALWAYS
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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14 - LECTURE 14 ANNOUNCEMENTS: READING & PROBLEMS...

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