19 - LECTURE 19 ANNOUNCEMENTS 1. QUIZ 5 RESULTS: A 20.4 sd...

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LECTURE 19 ANNOUNCEMENTS 1. QUIZ 5 RESULTS: A 20.4 sd 5.6 B 21.5 sd 6.1 C 22.6 sd 6.0 3. PyMOL ASSIGNMENT #6, CHYMOTRYPSIN 2. MIDTERM EXAM: THURS 10/20, 7:30 - 10PM; (ROOM TBA) MAKE-UP: SUN 10/23, 1 – 3:30 (e-MAIL PROF BY TODAY WITH CONFLICT!). ROOM TBA. WEDNESDAY S LECTURE TODAY 4. HOW TO STUDY FOR THE MIDTERM?! DISCUSS FRI 10/14 2:55PM COMSTOCK B108 LAST YEAR'S EXAM IS ON OUR WEB SITE; BE ABLE TO ANSWER ALL QUIZ, HOMEWORK QUESTIONS; UNDERSTAND EVERY WORD FROM LECTURES; USE THE TEXT AS A SUPPLEMENT 5. REMINDER: NO QUIZ WED 10/12 or 10/19 CONTROL OF ENZYME DEGRADATION PyMOL REVIEWS SUN 10/16 (CARPENTER); TU 10/18 (251 MALOTT). USUAL TIMES CONTROL OF ENZYME ACTIVITY 1. ALLOSTERIC; 2. COVALENT MODIFICATION CONTROL OF ENZYMES: REGULATION OF SYNTHESIS AND REGULATION OF BREAKDOWN OF THE PROTEIN ALLOSTERIC CONTROL VIA FEEDBACK INHIBITION: EXAMPLE OF ATCase
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ALLOSTERIC CONTROL EXAMPLE OF ASPARTATE CARBAMOYLTRANSFERASE ( ATCase ) 6 DIFFERENT ENZYME- CATALYZED RXNS ALLOSTERIC REGULATORS ( EFFECTORS ) 1. CTP IS NEGATIVE EFFECTOR, FAVORS T-STATE. SIGNAL THAT TOO MUCH PRODUCT IS BUILDING UP 2. ATP IS POSITIVE EFFECTOR, FAVORS R-STATE. SIGNAL THAT ENERGY SOURCE NOW AVAILABLE FOR NUCLEOTIDE SYNTHESIS 3. SUBSTRATES CARB. PHOS. AND ASP ARE POSITIVE EFFECTORS 2 3 4 5 6 7 + CARBAMOYL PHOSPHATE ASPARTATE N-CARBAMOYL ASPARTATE ATCase 1 + THE FIRST STEP IN SYNTHESIS OF THE NUCLEOTIDE, CTP FEEDBACK INHIBITION : CTP DOES NOT RESEMBLE SUBSTRATES CYTIDINE TRIPHOSPHATE, CTP A LINK BETWEEN AMINO ACID METABOLISM AND NUCLEOTIDE METABOLISM! COMPARE FEEDBACK INHIBITION TO SIMPLE INHIBITION BY FIRST PRODUCT: FEEDBACK TAKES INTO ACCOUNT MUCH MORE OF CELL'S METAB.
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell.

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19 - LECTURE 19 ANNOUNCEMENTS 1. QUIZ 5 RESULTS: A 20.4 sd...

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