22 - ANNOUNCEMENTS LECTURE 22 HOMEWORK, READING: AS IN LG...

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LECTURE 22 ANNOUNCEMENTS HOMEWORK, READING: AS IN LG FOR 10/21 & 10/24 PLUS THE PyMOL ASSIGNMENT #7, CARBOHYDRATES FRIDAY'S LECTURE CARBOHYDRATES: CHEMICAL STRUCTURE, LINKAGES; POLYMER FOR FUEL STORAGE; STRUCTURAL ROLE: CELLULOSE, CHITIN, GLYCOSAMINOGLYCANS TODAY CARBOHYDRATE STRUCTURAL AND RECOGNITION FUNCTIONS MIDTERM EXAM INFO THIS WEEK'S OFFICE HOURS AND REVIEW SESSIONS: IN THE USUAL ROOMS AT THE USUAL TIMES EXCEPT THAT PROF'S OFFICE HOURS ON THURSDAY 10/20 WILL RUN FROM 8AM - NOON. END OF TODAY'S LECTURE: INFO ABOUT MIDTERM EXAM INTRO TO BIOENERGETICS
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ELECTRON MICROSCOPE IMAGE OF PROTEOGLYCAN 300 nm BIG NEG. CHARGE BIND LOTS OF WATER FULLY EXTENDED, AND NON-INTERACTING WITH OTHER LIKE MOLECULES, i.e. SLIPPERY NOT MADE FROM TEMPLATE: REQUIRE AN ENZYME FOR EACH TYPE OF LINKAGE LUBRICATING FLUID IN JOINTS; MUCOUS COMPLEXITY! GLYCOSAMINOGLYCAN STRUCTURE HYALURONIC ACID LINKER PROTEIN CORE PROTEIN FOUND OUTSIDE OF CELLS; A MAIN COMPONENT OF EXTRACELLULAR MATRIX CHONDROITIN SULFATE KERATAN SULFATE
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PROTEOGLYCANS IN THE EXTRACELLULAR MATRIX (EM) ACTIN FILAMENTS PLASMA MEMBRANE LOOSE MESH OF PROTEOGLYCANS ALLOWS MOLECULES AS LARGE AS PROTEINS (OR EVEN VIRUSES!) TO REACH THE CELL SURFACE INSIDE THE CELL ROLES OF EM: 1. MECH. STRENGTH OF TISSUE/ORGAN; 2. CELLS WITHIN A TISSUE USE IT TO RECOGNIZE EACH OTHER AND DEVELOP SIMILARLY; 3. CELL MOTILITY AND BARRIERS TO MOTILITY DEPEND ON EM (BUT ARE LOST IN METASTASIS) "UNEXPECTED" FINDING: A CHONDROITIN SULFATE-RICH PROTEOGLYCAN IS A KEY BARRIER TO NERVE AXON REGENERATION INTEGRIN PROTEOGLYCAN FIBRONECTIN COLLAGEN EM
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MEMBRANE LIPID, SPHINGOMYELIN O-ANTIGEN A-ANTIGEN
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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22 - ANNOUNCEMENTS LECTURE 22 HOMEWORK, READING: AS IN LG...

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