23 - LECTURE 23 ANNOUNCEMENTS MIDTERM EXAM THURSDAY NIGHT...

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LECTURE 23 ANNOUNCEMENTS MIDTERM EXAM THURSDAY NIGHT 7:30 - 10PM. ROOM ASSIGNMENTS: LAST NAME N - Z IN ROCKEFELLER 203 (NEXT TO SCHWARTZ AUD.) LAST NAME A - M IN ROCKEFELLER SCHWARTZ AUDITORIUM THE MONDAY LECTURE HIGH-ENERGY MOLECULES TODAY'S LECTURE BIOENERGETICS: CONC EFFECTS; IONS CROSSING MEMBRANES; REDOX CARBOHYDRATE STRUCTURAL AND RECOGNITION ROLES HAVE A QUESTION DURING THE MIDTERM EXAM?! CLASS IS MOVED OUT OF STATLER ON FRIDAY!! STILL AT 10:10 – 11:00, BUT WE WILL BE IN IVES HALL ROOM 305. DOCUMENTARY ABOUT PREMATURE BIRTH, SAT 10/22 AT 7 PM MAJOR CONFERENCE AT CORNELL THIS SATURDAY 10/22, SPONSORED BY CORNELL HEALTH INTERNATIONAL OH @#$%&*!!
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WHY IS ATP A HIGH ENERGY COMPOUND ? 1. MORE RESONANCE STABILIZATION OF HYDROLYSIS PRODUCTS 2. BETTER SOLVATION OF PRODUCTS 3. DECREASED ELECTROSTATIC REPULSION IN PRODUCTS 4. FAVORABLE UPTAKE OF H + BY WATER ANCIENT BIOMOLECULE, PREDATING PROTEINS MANY MANY PROTEINS EVOLVED TO BIND ATP INSIDE CELL, ATP ALWAYS COMPLEXED TO METAL ION (Mg ++ ) THE 7 OXYGENS ARE NEARLY EQUIVALENT IN δ - ~ 0.7 BETWEEN EACH PHOSPHATE, THE BOND IS PHOSPHOANHYDRIDE (i.e. WATER IS REMOVED FROM 2 Pi) THE MOLECULE-BY-MOLECULE COMPARISON OF REACTANTS & PRODUCTS, i.e. G o TERMED Pi MEANING, PHOSPHATE Mg ++ (ALSO, [ADP] IS KEPT LOW IN ALL CELLS-- TRUE, BUT NOT A G o EFFECT) ATP + H 2 O ADP + Pi 3 2 1 BRIEF HISTORY OF ATP HO-P- OH + O - O H O-P-O - O - O O-P-O - + H 2 O O O - HO-P- O - O
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USING THE GIBBS FUNCTION G = G + RTln([PRODUCTS]/[REACTANTS]) o G = G o + RTln[NaCl] R /[NaCl] L (NaCl) (NaCl) LEFT RIGHT e.g. ATP + H 2 O ADP + P i + H + - 7 1. CHOOSE STANDARD STATE, e.g. 1 M AND ATM. PRESSURE 2. DIVIDE THE STAND. STATE INTO THE CONC UNITS NOW GONE!
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23 - LECTURE 23 ANNOUNCEMENTS MIDTERM EXAM THURSDAY NIGHT...

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