28 - ANNOUNCEMENTS LECTURE 28 1. QUIZ 7 THIS WEDNESDAY 11/2...

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LECTURE 28 1. QUIZ 7 THIS WEDNESDAY 11/2 (NO PyMOL). QUIZ 8 WILL BE WEDNESDAY, 11/9. QUIZ 9 WILL BE ON 11/16. THE LAST QUIZ, #10, WILL BE ON 11/30. 3. THIS WEEK'S ASSIGNMENTS AS IN LG, WITH THE EXCEPTION OF Ch15 #4. ANNOUNCEMENTS 2. MAKING HOLIDAY PLANS? NO LECTURE ON WED 11/23 . FRIDAY S LECTURE REGULATION OF HEXOKINASE IS DIFFERENT FOR 4 DIFFERENT ISOFORMS REGULATION OF GLYCOGEN PHOSPHORYLASE BY PHOSPHORYLATION AT SER-14 (HORMONAL CONTROL) AND BINDING (AMP OR ATP OR G6P) TO ALLOSTERIC SITE [AMP] IS THE SENSITIVE SIGNAL CORRESPONDING TO [ATP] TODAY: PFK-1, AND PK DIFFERENT TYPES OF ENERGY METABOLISM YIELD ATP AT DIFFERENT RATES: COOL! ALSO PyMOL: #8, PHOSPHOFRUCTOKINASE (NO PyMOL REVIEW TOMORROW) 4. WHEN STUDYING A METABOLIC PATHWAY…. NO GETTING AROUND IT! YOU MUST STUDY EACH STEP CAREFULLY ON YOUR OWN AT WHAT LEVEL OF DETAIL?! SEE LAST YEAR'S QUIZZES #7 & 8 5. RE-GRADING: ATTACH WRITTEN ARGUMENT TO EXAM, PLACE IN PURPLE FOLDER WHAT HAPPENS TO THE PYRUVATE THAT IS FORMED IN GLYCOLYSIS?
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T-STATE : R-STATE : ATP ADP CITRATE AMP PEP F-2,6-BP PHOSPHATASE STIMULATED! HYDROLYSIS OF F-2,6-BP ALLOSTERIC EFFECTORS OF PFK-1 HOW IS PFK-1 REGULATED IN DIFFERENT TISSUES? (IF PHOSPHATASE STIM.) SYN: F6P + ATP F-2,6-BP PFK-2 BREAKDOWN: F-2,6-BP F6P + Pi FBPase-2 KEY ROLE FOR SMALL MOLECULE F-2,6-BP TARGETS: ARG-ARG-(ANY)-SER * (OTHER PROTEINS, TOO) SO, LESS Glc USED UP BY LIVER HORMONE SIGNAL TO MOVE FAST!
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell.

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28 - ANNOUNCEMENTS LECTURE 28 1. QUIZ 7 THIS WEDNESDAY 11/2...

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