29 - Wednesday, November 2, 2011 Lecture 29 Announcements:...

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Wednesday, November 2, 2011 Lecture 29 Announcements: Want your midterm exam regraded? Submit for regrading by Friday 11/4 (the usual 1-week span after return of the exam) Info session about the HCEC process next spring: Friday 11/4 at 2:55PM in Comstock B108: How to write the personal statement (what are they looking for?). Let’s meet and set the date for the make-up final exam: check your calendars for conflicts! Then we will meet briefly right after the lecture on Wed 11/9 to choose the day and time for the make-up exam. A worthwhile lecture: Tomorrow, Thursday 11/3 at 8:00PM in Call Auditorium of Kennedy Hall, a talk by Nobelist Aaron Ciechanover: “Drug Development in the 21 st Century” Monday's lecture: hormonal vs local control: why different tissues respond differently control of pyruvate kinase: also hormonal and local control, also different tissues respond differently different rates of different ATP-producing rxns pentose phosphate pathway for synthesizing NADPH and pentoses Today's lecture: The pyruvate product of glycolysis must get into the mitochondrial matrix in order to undergo the further metabolism that will completely oxidize it to CO2 and give rise to many more ATPs. The outer mitochondrial membrane is full of holes . These holes are large enough that molecules up to10kD can pass through, so smaller molecules and ions also pass through this membrane freely-- the outer membrane does not serve as a barrier to small molecules and ions. Larger proteins cannot pass freely through this membrane. The inner membrane, on the other hand, is especially im permeable to ions and small molecules . Pyruvate (mw 87) can pass through the outer membrane to the inner membrane. It is then transported across the inner membrane, by a membrane-bound transport protein, into the mitochondrial matrix. Some notes on the mitochondrion, within which much metabolism occurs: One enzyme of the 8 enzymes of the Citric Acid Cycle is located within the bilayer of the inner mitochondrial membrane . That enzyme is succinate dehydrogenase . All of the other enzymes of the CAC are located in the aqueous mitochondrial matrix, as are the enzymes of fatty acid oxidation.
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29 - Wednesday, November 2, 2011 Lecture 29 Announcements:...

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