36 - LECTURE 36 ANNOUNCEMENTS 1. QUIZ 9: A 21.8 sd 7.0 B...

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LECTURE 36 ANNOUNCEMENTS 1. QUIZ 9: A 21.8 sd 7.0 B 23.2 sd 6.4 C 23.1 sd 7.0 WEDNESDAY S LECTURE TODAY BIOSYNTHESIS OF FATTY ACIDS SO-CALLED "FUTILE CYCLE" aka "SUBSTRATE CYCLE" SYNTHESIS OF GLUCOSE: GLUCONEOGENESIS EVENTS IN PSII . RAPID TRANSFER OF e - FROM P680*, EVENTUALLY TO MOBILE QUINONOL . BUILD-UP OF 4 POSITIVE CHARGES IN THE OEC, THEN OX. OF 2H 2 O . 4H + PUMPED FROM STROMA INTO LUMEN FOR EACH O 2 EVOLVED AT CYT-bf (SIMILAR TO COMPLEX III IN MITOCHONDRIA) . Q-CYCLE OCCURS, WITH H + PUMPING; WATER-SOL. REDUCED PROTEIN PRODUCT, PLASTOCYANIN 2. HOW TO STUDY THIS MASS OF FACTS RE OX PHOS AND PHOTOSYNTHESIS?! USE LAST YEAR'S QUIZZES AS A GUIDE GENERAL “TESTING PLAN” IS TO SHOW SOME STEP(S) AND ASK "WHAT HAPPENS?” AT PSI, e - FROM PLASTOCYANIN USED TO FORM NADPH H + GRADIENT ACROSS THYLAKOID USED IN CHLOROPLAST TO SYNTHESIZE ATP
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METABOLISM: BIOSYNTHESIS ANABOLISM METABOLISM UNTIL NOW: BIOENERGETICS -- HOW SUGARS, FATS, AND AA ARE OXIDIZED TO PRODUCE ATP; HOW ENERGY IN SUNLIGHT ATP AND NADPH BIOSYNTHETIC PATHWAYS THAT WE WILL STUDY: START: GLUCONEOGENESIS, NEW GLUCOSE FORMATION FROM NON- SUGAR PRECURSORS BRAIN AND NERVES USE 3/4 OF BODY’S GLUCOSE. THEY PERFORM SOME GLUCONEOGENESIS (BUT NO FAT SYN: THEY STORE ALMOST NO FAT) ENOUGH GLUCOSE STORED AS GLYCOGEN FOR ~1 DAY’S NEEDS BODY MUST CONTINUOUSLY SYNTHESIZE GLUCOSE. NOT INTERCONVERSION OF SUGARS FACTS ABOUT USE OF GLUCOSE AS FUEL : RED BLOOD CELLS ALSO STORE NO FAT USE GLUCOSE. SKELETAL MUSCLE CELLS DO STORE FAT, AND USE GLUCOSE. 90% OF GLUCONEOGENESIS OCCURS IN LIVER. MOST OF THE REST IN MUSCLE AND NERVE (1) CARBOs; (2) LIPIDS; (3) N-CONTAINING MOLECULES
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GLUCONEOGENESIS DOWN ARROWS SHOW GLYCOLYSIS UP ARROWS SHOW GLUCONEOGENESIS GLUCONEOGENESIS IS AN ANCIENT PATHWAY AT MOST STEPS: REVERSAL OF GLYCOLYSIS! ( G ~0) i.e. EXACTLY THE SAME RXNS, SAME ENZYMES!
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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36 - LECTURE 36 ANNOUNCEMENTS 1. QUIZ 9: A 21.8 sd 7.0 B...

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