37 - LECTURE 37 ANNOUNCEMENTS 1. READING AS IN LG FOR 11/21...

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LECTURE 37 ANNOUNCEMENTS 1. READING AS IN LG FOR 11/21 & 11/23; PROBLEMS AS IN LG FOR THIS WEEK. 2. MAKE-UP QUIZ WED 11/30. COVERS LECTURES 11/14, 11/16, 11/18, AND TODAY. TURN IN THE MAKE-UP QUIZ ONLY IF FEWER THAN 9 QUIZZES HAVE BEEN PREVIOUSLY TAKEN . YOU MIGHT HAVE MISSED ONE OF THOSE 9 QUIZZES FOR ANY REASON-- THE REASON IS NOT IMPORTANT, YOU CAN TAKE THAT LAST QUIZ. 3. MUST LET PROF KNOW ABOUT FINAL EXAM CONFLICT BEFORE NOON ON WED 11/30. FRIDAY S LECTURE 2. CALVIN CYCLE: 3 STAGES, (i) FIX CO 2 ; (ii) SYN SUGAR; (iii) REGENERATE Ru-1,5-BP TODAY BIOSYN OF FAT AND PHOSPHOLIPID THE CHOLESTEROL STORY FA BIOSYN; LOCAL AND HORMONAL CONTROL 1. GLUCONEOGENESIS MAIN SITE IS THE LIVER; MAIN STARTING MOLECULES: LACTATE AND ALA "BYPASS" OF ONLY 3 STEPS OF GLYCOLYSIS MAIN REGULATION: PYRUVATE CARBOXYLASE REQUIRES ACETYL-CoA
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LIPID BIOSYNTHESIS: FATTY ACIDS I N M T O C H D R IN CYTOSOL 1. NO ENZYMES IN COMMON 2. e - CARRIER IS NADPH FOR BIOSYN (NADH & FADH2 FOR β -OX) 3. MALONYL-CoA HAS KEY ROLE IN BIOSYN 4. IN ANIMAL CELLS, BIOSYN IN CYTOSOL WHEREAS β -OX IS IN MITOCHON MATRIX A KEY PRINCIPLE: UNSTABLE = REACTIVE 3-CARBON MALONYL IS USED INSTEAD OF STABLE 2-CARBON ACETYL TO ADD 2-CARBON UNITS WITH BIOSYNTHESIS OF PALMITIC ACID COMPARE TOTAL RXN OF 16:0 FATTY ACID BY b-OXIDATION JARGON ALERT : CYTOSOL NOT INSIDE AN ORGANELLE
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MALONYL-CoA BIOSYNTHESIS IN CYTOSOL ACETYL- CoA CITRATE OXALOACETATE MALATE PYRUVATE CAC RXNS CITRATE MALATE PYRUVATE OXALOACETATE CoA ACETYL-CoA U NADH NAD+ NADP+ NADPH + CO2 C Y T O S O L M I T O C H O N CH 3 C-S-CoA + ATP + HCO 3 O CCH 2 C-S-CoA + ADP + Pi + H O O - - O + ACETYL-CoA CARBOXYLASE BIOTIN ACETYL-CoA CARBOXYLASE ATP + HCO 3 - ADP P i
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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37 - LECTURE 37 ANNOUNCEMENTS 1. READING AS IN LG FOR 11/21...

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