38 - LECTURE 38 ANNOUNCEMENTS 1. READING AND PROBLEMS AS IN...

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LECTURE 38 ANNOUNCEMENTS 1. READING AND PROBLEMS AS IN LG 2. LAST PyMOL ASSIGNMENT: G-PROTEINS (THE ONLY PyMOL ON FINAL EXAM). MONDAY'S LECTURE: TODAY BIOSYNTHESIS OF NITROGEN-CONTAINING MOLECULES: 3. PLEASE DO EVALUATE THIS COURSE ONLINE. WE GREATLY APPRECIATE YOUR DOING THIS!! LIPID BIOSYNTHESIS: CONTROL OF FATTY ACID SYNTHESIS: ACETYL CoA-CARBOXYLASE MINIMIZING A SUBSTRATE CYCLE OF FA SYNTHESIS AND FA β -OXIDATION SYNTHESIS OF FAT AND PHOSPHOLIPID CHOLESTEROL SYNTHESIS "FIXING" N 2 FROM THE ATMOSPHERE INCORPORATING N INTO OTHER BIOMOLECULES CONTROL OF ALL METABOLISM-- INTRO 4. DO NOT TURN IN QUIZ 10 IF YOU HAVE ALREADY COMPLETED 9 QUIZZES! PATHOLOGY IN ARTERIES CAUSED BY "CHOLESTEROL" 5. REVIEWS/OFFICE HRS FOR STUDY WEEK ARE NOW POSTED ON BLACKBOARD. MON REVIEW WILL COVER THE ~ FIRST HALF, TUE THE ~ SECOND HALF OF THE COURSE. CHOLESTEROL TRANSPORT TO TISSUES
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LIPOPROTEINS: DELIVERY OF CHOLESTEROL ESTERS TO TISSUES DIET CHYLOMICRONS SYN. IN LIVER VLDL HDL LDL t 1/2 ~ 10 min PATHOLOGY: DIRECTLY FROM DEFINITION: t 1/2 = TIME FOR INITIAL CONC TO BE REDUCED BY HALF (HALF-LIFE) 99% LIPID, 1% PROTEIN; ~200nm; SYN IN INTESTINE ER AFTER MEAL 90% LIPID, 10% PROTEIN; ~50nm; CONTINUALLY LOSING TAG BY ACTION OF TAG LIPASE L OW D ENSITY L IPOPROTEIN t 1/2 ~ 1 day 75% LIPID, MOSTLY CHOLESTEROL ESTER 25% PROTEIN; ~20nm H IGH D ENSITY L IPOPROTEIN t 1/2 ~ 5 days V ERY L OW D ENSITY L IPOPROTEIN t 1/2 ~ 30 min 67% LIPID, 33% PROTEIN; ~10nm REMNANT OF VLDL; DELIVERS CHOL ESTERS TO TISSUE, OR ELSE IS TAKEN UP BY LIVER PICKS UP EXCESS CHOLESTEROL FROM TISSUE, THEN IS TAKEN UP BY LIVER ONLY SIGNIF. SITE FOR CHOLESTEROL DESTRUCTION ! COMPLICATION FOR STUDY: EACH LIPOPROTEIN IS CONTINUALLY CHANGING SIZE AND COMPOSITION! ARTERY: ENDOTHELIAL CELL LAYER SHOULD BE SMOOTH LOW-RESISTANCE BLOOD FLOW DAMAGE TO ARTERY: TURBULENT FLOW (HYPERTENSION); VIRUSES; BACTERIA DAMAGE TO LDL: OXIDATION or FREE RADICALS LDL CONC. IN BLOOD TOO HIGH (WANT LDL REMOVED FROM BLOOD TO TISSUE OR LIVER- - THAT IS HEALTHY!) ARTERY
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NORMAL, HEALTHY CELLULAR UPTAKE OF LDL LDL ApoB-100 LDL RECEPTOR
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell.

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38 - LECTURE 38 ANNOUNCEMENTS 1. READING AND PROBLEMS AS IN...

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