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Unformatted text preview: Net ID BIOMG 3310 MIDTERM EXAM 10/21/10 1. 2. 3. 4. 5. 6. 7. 8. 9. 10. 11. 12. 13. 14. 15. 16. 17. TOTAL BE SURE TO WRITE/PRINT LEGIBLY . IF WE CAN'T READ IT, WE CAN'T GRADE IT! (SERIOUSLY) PRINT NAME (LAST, FIRST) ON THE BACK TOP OF THE LAST PAGE AND ONLY THE LAST PAGE Use these pK a values unless others are given in a problem: terminal COOH 4 terminal NH 3 + 9 R-GROUPS: Asp 4 Glu 4 Cys 8 Tyr 10 His 7 Lys 10 Arg 12 1. (7 pts) Given that the side chain of Ala is -CH 3 . a . On the right, draw Ala at pH 7. Show every atom. Use symbols and to label those carbons. b . Below, draw Ala-Ala at pH 7. Circle the 6 atoms that line in a plane. 2. (10 pts) Hb has a terminal amino and a terminal carboxyl that can form an ion pair. a. What fraction of these ionizable groups are actually in an ion pair: ______ at pH 7.5 ______ at pH 7.0 b. Draw curves of vs pO 2 that correspond to pH values in question 2a. Label curves and axes, and show at least two numerical values on each axis. c. Which curve(s) in 2b involve BPG that stays bound to the Hb at all the values of pO 2 shown on your graph? Circle answer: pH 7.5 pH 7.0 both curves neither curve 3. (2 pts) Circle each pair below that are isozymes: Hb/Mb hexose/hexokinase muscle hexokinase/brain hexokinase tyrosine kinase/serine kinase 4. (5 pts) We know that O 2 binds to the heme Fe ++ of Mb. Then why is the polypeptide needed?! a. Briefly (BRIEFLY) describe two important properties of the Mb polypeptide : i....
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).
- Fall '11