NIF-K - Net ID KEY BIOMG 3310 FINAL EXAM 12/13/10 1a b. c....

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Net ID KEY BIOMG 3310 FINAL EXAM 12/13/10 1 a b. c. 2 a. b. c. 3 a. b. c. d. e. f. g. h. i. j. k. 4 a. b. c. d. 5 a. b. c. 6 TOTAL LAST PAGE: CHART OF "ALL METABOLISM" PRINT NAME (LAST, FIRST) ON THE BACK TOP OF THE LAST PAGE ONLY
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1. QUESTIONS ABOUT DRAWING MOLECULES a. (3 pts). Draw the structure of the triacylglycerol having all acyl chains 5:1 Δ 3 . Show all atoms. b. (6 pts) Draw the structure of Gly-Cys at pH 7 . Cys sidechain is CH 2 SH, pKa = 8. Terminal amino pKa = 9 and terminal carboxyl pKa = 4. Show every atom. Pick one of the C α , label it, and show the ϕ and ψ angles. c. (4 pts) Start with CH 4 . Draw 4 more 1-carbon molecules showing increasing levels of oxidation . Draw all atoms! CH 4 CH 3 OH C = O CH-OH O = C = O 2. QUESTIONS ABOUT PROTEIN STRUCTURE AND PROPERTIES a . (3 pts) Which of the following bind to Hb at the same site where O 2 binds? Circle the letters: A. H + B. CO 2 C. CO D. BPG E. ATP F. AMP O || H H
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b. (5 pts) One ion pair in deoxyhemoglobin can form between His146 and Asp94. Given a His pKa = 7.0 and the Asp pKa = 4.0, and choosing the best answer from the list below , what fraction of the His146 - Asp94 are actually in an ion pair at the following pH values: Use one of these choices for each answer: 0.001 | 0.01 | 0.10 | 0.20 | 0.50 | 0.80 | 0.90 | 0.99 pH3 _ 0.1 pH4 _ 0.5 pH5 _ 0.9 pH6 _ 0.9 pH7 _ 0.5 c. (6 pts) Circle T if true or F if false about what is revealed in the Ramachandran Map below showing all residues of a real protein of unknown AA sequence: T / F The II structures of the protein T / F The I structure of the protein T / F The type of structural domain T / F The actual values of Φ and Ψ at every C α T / F The H-bonding pattern T / F Stability of the protein 3. QUESTIONS ABOUT METABOLISM AND CONTROL OF METABOLISM a. (4 pts) Consider a fatty acid (FA) that must cross a plasma membrane (PM) in order to enter a cell and eventually to undergo β -oxidation. In [i - iv] below, circle each of the correct choices. i. The FA will cross the PM faster if it is in the form {R-COOH or R-COO - }. ii. After it is inside the cytosol, the FA first forms the {acyl adenylate or acyl-CoA }. iii. Formation of PP i drives the rxn in (ii) because (circle A or B or C below): A. PP i is very stable due to the resonance in its anhydride bond B. PP i hydrolysis is so favorable due to resonance stabilization of the products C. PP i it used up by the cell for lipid and cholesterol biosynthesis iv. The rate of FA transport across the inner mitochondrial membrane will be slowed by the presence of {malonyl-CoA or acetyl-CoA or citrate or palmitoyl-CoA } b. (4 pts) Regarding control of fatty acid synthesis , name (abbreviations OK) the molecules indicated: One hormone, INSULIN and one small molecule, CITRATE that promot e FA synthesis One hormone, GLUCAGON OR EPINEPHRINE and one small molecule, PALMITOYL-COA that inhibit FA synthesis
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c. (2 pts) In general, different cells (e.g. in different tissues) respond differently to hormones.
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This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell University (Engineering School).

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NIF-K - Net ID KEY BIOMG 3310 FINAL EXAM 12/13/10 1a b. c....

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