Pymol 10 - Pymol 10 Today we are going to be talking about...

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Pymol 10 Today we are going to be talking about specifically a trimeric G-protein. A G-protein is a GTP-binding protein. All G-proteins range in activity when bond to GDP or GTP. Hormone Signaling Summary: Cell membrane has GPCR embedded in it. Hetetrotrimeric (3 different subunits), G-proteins bind to these GPCR. Epinephrine binds to GPCR, but that changes conformation and the alpha subunit detaches from the GPCR. Alpha and beta-gamma (stick together). Talk mostly about Alpha subunit. Alpha subunit can bind and activate an enzyme adenylate cyclase (found in membrane). Adenylate cyclase makes cyclic-AMP (cAMP) from ATP Change in conformation, and GDP leaves from the binding site. Then a GTp comes along and binds, which is responsible for the active form of the Alpha subunit. 2) How does alpha subunit interact with adenylate cyclase Structure of heterotrimeric G-protein
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red is alpha cyan is beta magenta is gamma GDP is inside GDP is inside because if it were GTP, then there would be no heterotrimeric subunit.
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Pymol 10 - Pymol 10 Today we are going to be talking about...

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