PYMOL NOTES - Ask her if on Tuesday shes going to be doing...

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Ask her if on Tuesday she’s going to be doing the same review in Malott Hall Zymogen Chymotrypsinogen Chymotrypsin 1) aromatic peptide bonding 2) cleave peptide bonds. (Catalysis) structurally, the 3 rd thing that it needs to do is 3) Stabilize tetrahedral – oxyanion hole. N-H groups Salt bridge is cleaved Chymotripsinogen Not very good Does not bind very well to the substrate and Memorize the catalytic triad How does chymotrypsin achieve its catalytic activity What are the Look at all the residues that are very essential for catalytic activity in chymotrypsin What composes the catalytic triad? SER-195, HIS 57, ASP 102 What does serine 195 do? It has 2 roles: catalytic role: it has a OH group. In order to break a peptide bond, the O needs to become attached to the peptide bond you want to break. So the OH group initiates a nucleophilic attack End up forming tetrahedral intermediate imp’t for 2 nd role: its related to the tetrahedral intermediate least stable transition state of
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PYMOL NOTES - Ask her if on Tuesday shes going to be doing...

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