# 4 - NET ID BIOMG 3310 QUIZ 4a 1(9 pts Write R if the...

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NET ID __________ BIOMG 3310 QUIZ 4a 9/29/10 1. (9 pts) Write R if the relaxed state is favored by the procedure below , or T if the tense state is favored, or N if there is a negligible effect of the following procedures: pH is raised from 6.6 to 7.1 O 2 concentration in the lungs is raised from pO 2 = 100 mmHg to pO 2 = 120 mmHg [BPG] in red blood cells drops in half CO 2 concentration in red blood cells increases sharply α 2 γ 2 fetal Hb becomes α 2 β 2 adult Hb tissue near the red blood cells becomes metabolically active O 2 concentration is raised from pO 2 = 10 mmHg to pO 2 = 90 mmHg _____ Hb is mutated from normal adult Hb to a Hb with Hill Equation parameters n = 2.8, P 50 = 2 mmHg _____ The two His143 binding to BPG are mutated to Ser 2. (8 pts) You have determined the parameters of the Hill Equation for several different forms of Hb, under different conditions. In the spaces below, write the letter of the Hill Equation values that fits the description, followed by the number of the plot that also fits the description. Yes, you must use some letter + number combinations more than once. letter plot number ____ ____ highest cooperativity for O 2 binding A . n = 3, P50 = 45 mmHg ____ ____ lowest cooperativity for O 2 binding B . n = 1.5, P50 = 1.8 mmHg ____ ____ normal adult Hb C . n = 2.8, P50 = 26 mmHg ____ ____ fetal Hb D . n = 2.8, P50 = 20 mmHg ____ ____ highest O 2 affinity at all pO 2 E . n = 1, P50 = 150 mmHg ____ ____ Hb that is locked in the T-state ____ ____ lowest O 2 affinity at all pO 2 ____ ____ Hb that is locked in the R-state pO 2 , mmHg 3. (7 pts) Circle the correct answers below: a. T/F The α and the β chains of Hb have AA sequence that is nearly identical to AA sequence of Mb. b. T/F The α chain of Hb is mostly α -helix, whereas the β chain of Hb is mostly β -sheet. c. T/F The IV structure of Hb does not depend much on ion pair electrostatic attraction. d. T/F The sigmoid O 2 binding curve of Hb describes, in part, the higher O 2 affinity of Hb compared with Mb e. T/F The O 2 binding curve of Hb has sigmoid shape, starting in the T-state at low pO 2 , then switching to the R-state at higher pO 2 f. T/F

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## This note was uploaded on 01/01/2012 for the course BIOMG 3310 taught by Professor Feigenson during the Fall '11 term at Cornell.

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4 - NET ID BIOMG 3310 QUIZ 4a 1(9 pts Write R if the...

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