4K - NET ID _Key A_ BIOMG 3310 QUIZ 4a 9/29/10 1. (9 pts)...

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NET ID __Key A __ BIOMG 3310 QUIZ 4a 9/29/10 1. (9 pts) Write R if the relaxed state is favored by the procedure below , or T if the tense state is favored, or N if there is a negligible effect of the following procedures: __R_ pH is raised from 6.6 to 7.1 __N_ O 2 concentration in the lungs is raised from pO 2 = 100 mmHg to pO 2 = 120 mmHg __R__ [BPG] in red blood cells drops in half __T_ CO 2 concentration in red blood cells increases sharply __T_ α 2 γ 2 fetal Hb becomes α 2 β 2 adult Hb __T_ tissue near the red blood cells becomes metabolically active __R_ O 2 concentration is raised from pO 2 = 10 mmHg to pO 2 = 90 mmHg __R_ Hb is mutated from normal adult Hb to a Hb with Hill Equation parameters n = 2.8, P 50 = 2 mmHg __R_ The two His143 binding to BPG are mutated to Ser 2. (8 pts) You have determined the parameters of the Hill Equation for several different forms of Hb, under different conditions. In the spaces below, write the letter of the Hill Equation values that fits the description, followed by the number of the plot that also fits the description. Yes, you must use some letter + number combinations more than once. letter plot number _ A _ __ 4 _ highest cooperativity for O 2 binding A . n = 3, P50 = 45 mmHg _ E __ __ 5 _ lowest cooperativity for O 2 binding B . n = 1.5, P50 = 1.8 mmHg _ C _ __ 3 _ normal adult Hb C . n = 2.8, P50 = 26 mmHg _ D __ __ 2 _ fetal Hb D . n = 2.8, P50 = 20 mmHg _ B __ __ 1 _ highest O 2 affinity at all pO 2 E . n = 1, P50 = 150 mmHg _ E __ __ 5 _ Hb that is locked in the T-state _ E __ __ 5 _ lowest O 2 affinity at all pO 2 _ B __ __ 1 _ Hb that is locked in the R-state pO 2 , mmHg 3. (7 pts) Circle the correct answers below: a. T/F The α and the β chains of Hb have AA sequence that is nearly identical to AA sequence of Mb. b. T/F The α chain of Hb is mostly α -helix, whereas the β chain of Hb is mostly β -sheet. c. T/F The IV structure of Hb does not depend much on ion pair electrostatic attraction. d.
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4K - NET ID _Key A_ BIOMG 3310 QUIZ 4a 9/29/10 1. (9 pts)...

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