Drugs and Aging - DRUGS AND AGING KILLINGER-HEALTHY AGING...

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DRUGS AND AGING KILLINGER-HEALTHY AGING How drug action is altered in older patients: Absorption of drugs into system: ↓ digestive enzymes ↓ acidity in stomach ↓ gastric motility ↓ intestinal blood flow Slower movement through GI tract Distribution of drugs in body: ↓ cardiac output and reserve ↓ blood flow to target tissues ↓ lean body mass Metabolism of drugs: ↓ metabolism of drug ↓ hepatic biotransformation Elimination of drugs from body: ↓ renal excretion of drugs ↓ respiratory transfer ↓ number of drug receptors Variability of receptor sensitivity ↑ fatty tissue ↓ total body water Classes of drugs that cause confusion in older adults: Antiarrhythmics Anticholinergics Anitemetics Antihistamines Antihypertensives Anitparkinsonian agents Antipsychotics Diuretics Histamine blockers Narcotic analgesics Sedative hypnotics Tranquilizers Inappropriate drugs for older patients: Drug: Reason for exclusion Amitriptyline Other antidepressants cause fewer adverse reactions Carisprodol Potential toxic reaction is greater than potential benefit
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Drugs and Aging - DRUGS AND AGING KILLINGER-HEALTHY AGING...

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