Womens Health initiative

Womens Health initiative - Women’s Health And The...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Women’s Health And The Women’s Health And The Women’s Health Initiative Study Lisa Killinger, DC The Women's Health Initiative The (WHI) is a major 15­year research program to address the most common causes of death, disability and poor quality of life in postmenopausal women ­­ Primary topics studied: Primary topics studied: • cardiovascular disease • cancer • osteoporosis More on the WHI More on the WHI • • • • • Launched in 1991 A set of clinical trials One observational study Involve more than 161,000 women Mostly healthy & postmenopausal Randomized Clinical Trial (RCT) Randomized Clinical Trial (RCT) • Hormone Replacement Therapy Trial (HRT) • Dietary Modification Trial (DM) • Calcium/Vitamin D Supplementation Trial (CaD) Observational Study (OS) Observational Study (OS) • OS Participants: – From 40 Clinical Centers (CC) nationwide – 167,000 women aged 50­79; 67,000 in RCT 100,000 in OS – 20% overall minority recruitment: 10 CC's with goal of 60% Community Prevention Study Community Prevention Study (CPS) • CPS Participants: – at CDC funded University­based Prevention Research Centers CPS Study Topics CPS Study Topics • Reducing CVD Risk Among Black Women • • • • (Johns Hopkins) CVD Peer Support in Afr­American Women (U Alabama) Environmental Factors & Physical Activity in Women (SLU) Osteoporosis Prevention (UNC; Chapel Hill) Diabetes Care in Minority Women (UNC) WHI­ HRT study WHI­ HRT study The “pill” and its effect on women • • • • • Heart Disease Breast Cancer Osteoporosis Stroke Dementia Estrogen + Progestin vs. Placebo Estrogen + Progestin vs. Placebo The rate per 10,000 women per year Breast Cancer Heart Attack Stroke Blood Clots Hip Fracture Colorectal Cancer Placebo Pills Estrogen Plus Progestin Pills 30 30 38 37 15 16 10 10 21 16 29 34 Summary of Results: Heart Summary of Results: Heart • Women on Estrogen/Progest Pill not protected from heart disease • E & P: 24% Increase in heart disease risk • Highest risk increase in women w/ hi LDL Manson, et al. NEJM Aug 7, 2003. Vol. 349(6):523­534. Summary of Results: Summary of Results: Breast Cancer • E & P Group: 24% increase in Breast Cancer risk Chebowski, et al. JAMA 2002 June 225. Vol. 289(24): 3243­3254. Results: Dementia Results: Dementia • May, 20, 2003 JAMA • E&P Group: Twice the risk of dementia (Alzheimer’s) • Resource Orgs: – www.alzheimers.org – ADEAR: 1­800­438­4380 Other Results… Other Results… • E&P and Stroke: Risk increased 31% • E &P and Blood Clots: Risk increased 61% • Osteoporosis and Colorectal Cancer: E&P may protect, but risks outweigh the benefits • E&P part of study was cancelled due to increased rates of disease! Resources on Women’s Health Resources on Women’s Health • • • • www.4women.org Nat’l Women’s Health Info Center 1­800­994­Woman www.nhlbi.nih.gov/whi (women’s health init) • National Domestic Abuse Hotline: 1­800­ 799­SAFE (violence is a leading cause of injury in women ages 15­54) ...
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern